Wikipedia

C11orf16

Gene C11orf16, chromosome 11 open reading frame 16, is a protein in humans that is encoded by the C11orf16 gene.[5][6] It has 7 exons, and the size of 467 amino acids.

C11orf16
Identifiers
AliasesC11orf16, chromosome 11 open reading frame 16
External IDsMGI: 1928824; HomoloGene: 49631; GeneCards: C11orf16; OMA:C11orf16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

56673

57355

Ensembl

ENSG00000176029

ENSMUSG00000031022

UniProt

Q9NQ32

Q9JJR6

RefSeq (mRNA)

NM_020643

NM_001040700
NM_020609

RefSeq (protein)

NP_065694

NP_001035790

Location (UCSC)Chr 11: 8.92 – 8.93 MbChr 7: 109.31 – 109.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

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Location

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The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.

 

Gene neighborhood

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Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on chromosome 11.

Expression

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Human

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The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.

 
C11orf16 expression in human body sites extracted from NCBI GEO profile

Mouse brain

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Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.

Transcription factors

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Some transcription factors that have the higher matrix similarity are Kruppel-like zinc finger protein 219, zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.[7]

mRNA

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Isoform

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The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.[8]

Homology

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Paralogs

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No paralogs were found for the C11orf16 gene through NCBI BLAST.

Orthologs

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Description Common name NCBI accession ID Query cover E value Identity Date of divergence (MYA)
Homo sapiens Human NP_065694.2 100 % 0 100% N/A
Pongo abelii Sumatran orangutan PNJ24628 84% 0 95% 15.2
Aotus nancymaae Nancy Ma's night monkey XP_012312127.1 88% 0 84% 42.6
Chinchilla lanigera Long-tailed chinchilla XP_013367496.1 97% 0 68% 88
Equus przewalskii Przewalski's horse XP_008512245.1 98% 0 73% 94
Cervus elaphus hippelaphus Central European red deer OWK17675.1 99% 0 67% 94
Hipposideros armiger Great roundleaf bat XP_019511755.1 99% 0 65% 94
Neomonachus schauinslandi Hawaiian monk seal XP_021541375.1 99% 0 66% 94
Lipotes vexillifer Baiji XP_007459933.1 98% 0 68% 94
Myotis brandtii Brandt's bat XP_005874017.1 98% 1e-174 67% 94
Chelonia mydas Green sea turtle XP_007057171.1 83% 1e-57 37% 320
Balearica regulorum gibbericeps Grey crowned crane XP_010311948.1 70% 6e-5 40% 320

Conservation

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The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.

 
The multiple sequence alignment shows the conservation of the gene C11orf16

Protein

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Molecular weight

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The predicted molecular weight of the protein encoded by C11orf16 is 51 kilodaltons.[9][10]

Domains and motifs

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Several protein domains and motifs were found including CHD5-like protein, tyrosine kinase phosphorylation site, protein kinase C phosphorylation site, N-myristoylation site, casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site.[11] The picture indicates the location of the motifs.

 
The predicted motifs of C11orf16 are shown in colors to the corresponding amino acids

Secondary structure

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The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.

 
The secondary structure of protein C11orf16

Post-translational modifications

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No transmembrane helices,[12] potential GPI-modification sites, or TM-proteins were found. There were seven predicted sumoylation sites,[13] multiple phosporylation sites with most of them being unspecified,[citation needed] and nine glycosylation sites.[14]

 
Post translational modification of protein C11orf16[15]

Subcellular localization predictor

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The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.[16]

Protein interaction

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Proteins C1orf105 (Chromosome 1 open reading frame 105), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16.[17]

Clinical significance

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Disease association

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Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process.[18]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176029 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031022 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Amid C, Bahr A, Mujica A, Sampson N, Bikar SE, Winterpacht A, Zabel B, Hankeln T, Schmidt ER (Aug 2001). "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7". Cytogenet Cell Genet. 93 (3–4): 284–90. doi:10.1159/000056999. PMID 11528127. S2CID 27611036.
  6. ^ "Entrez Gene: C11orf16 chromosome 11 open reading frame 16".
  7. ^ "Genomatix". Archived from the original on 2021-08-17. Retrieved 2018-05-06.
  8. ^ "NCBI Nucleotide". 22 November 2021.
  9. ^ "Expasy".
  10. ^ "Sigma Antibodies".
  11. ^ "Motif Scan".
  12. ^ "TMHMM".
  13. ^ "SUMOplot".
  14. ^ "YingOYang".
  15. ^ "Protter".
  16. ^ "PSORTII".[permanent dead link‍]
  17. ^ "String".
  18. ^ "SWISS-MODEL". Archived from the original on 2018-05-07. Retrieved 2018-05-06.
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Further reading

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