BET1

BET1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EGX
Identifiers
Aliases	BET1, HBet1 golgi vesicular membrane trafficking protein
External IDs	OMIM: 605456; MGI: 1343104; HomoloGene: 38108; GeneCards: BET1; OMA:BET1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	94,004,382 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	4,086,972 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; Achilles tendon; ; placenta; ; endometrium; ; corpus epididymis; ; anterior pituitary; ; monocyte; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland;
	Top expressed in
	gastrula; ; decidua; ; right kidney; ; ventricular zone; ; lip; ; seminal vesicula; ; lacrimal gland; ; otic placode; ; morula; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; syntaxin binding; SNAP receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi cisterna; Golgi membrane; cis-Golgi network; transport vesicle; SNARE complex; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi trans cisterna; integral component of Golgi membrane;
Biological process	vesicle fusion with Golgi apparatus; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; protein transport; vesicle-mediated transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	10282
	12068
	ENSG00000105829
	ENSMUSG00000032757
	O15155
	O35623
	NM_005868; NM_001317739
	NM_009748
	NP_001304668; NP_005859
	NP_033878
	Wikidata
View/Edit Human	View/Edit Mouse

BET1 homolog is a protein that in humans is encoded by the BET1 gene.^[5]^[6]^[7]

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105829 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang T, Wong SH, Tang BL, Xu Y, Peter F, Subramaniam VN, Hong W (Dec 1997). "The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus". J Cell Biol. 139 (5): 1157–68. doi:10.1083/jcb.139.5.1157. PMC 2140212. PMID 9382863.1157-68&rft.date=1997-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140212#id-name=PMC&rft_id=info:pmid/9382863&rft_id=info:doi/10.1083/jcb.139.5.1157&rft.aulast=Zhang&rft.aufirst=T&rft.au=Wong, SH&rft.au=Tang, BL&rft.au=Xu, Y&rft.au=Peter, F&rft.au=Subramaniam, VN&rft.au=Hong, W&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140212&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
^ Waters MG, Pfeffer SR (Nov 1999). "Membrane tethering in intracellular transport". Curr Opin Cell Biol. 11 (4): 453–9. doi:10.1016/S0955-0674(99)80065-9. PMID 10449330.453-9&rft.date=1999-11&rft_id=info:doi/10.1016/S0955-0674(99)80065-9&rft_id=info:pmid/10449330&rft.aulast=Waters&rft.aufirst=MG&rft.au=Pfeffer, SR&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
^ ^a ^b "Entrez Gene: BET1 BET1 homolog (S. cerevisiae)".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev, B&rft.au=Gnad, F&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan, K&rft.au=Hao, T&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.157-64&rft.date=2003&rft_id=info:pmid/12853948&rft_id=info:doi/10.1038/nature01782&rft_id=info:bibcode/2003Natur.424..157H&rft.aulast=Hillier&rft.aufirst=LW&rft.au=Fulton, RS&rft.au=Fulton, LA&rft_id=https://doi.org/10.1038%2Fnature01782&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.767-72&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961#id-name=PMC&rft_id=info:pmid/12690205&rft_id=info:doi/10.1126/science.1083423&rft_id=info:bibcode/2003Sci...300..767S&rft.aulast=Scherer&rft.aufirst=SW&rft.au=Cheung, J&rft.au=MacDonald, JR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882961&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.27480-7&rft.date=2001&rft_id=info:doi/10.1074/jbc.M102786200&rft_id=info:pmid/11323436&rft.aulast=Zhang&rft.aufirst=T&rft.au=Hong, W&rft_id=https://doi.org/10.1074%2Fjbc.M102786200&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.1097-108&rft.date=1999&rft_id=info:doi/10.1101/gr.8.11.1097&rft_id=info:pmid/9847074&rft.aulast=Sanger Centre&rft.aufirst=The&rft.au=Washington University Genome Sequencing Cente, The&rft_id=https://doi.org/10.1101%2Fgr.8.11.1097&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.149-58&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:8682509#id-name=S2CID&rft_id=info:pmid/9094723&rft_id=info:doi/10.1016/S0092-8674(00)80191-9&rft.aulast=Hay&rft.aufirst=JC&rft.au=Chao, DS&rft.au=Kuo, CS&rft.au=Scheller, RH&rft_id=https://doi.org/10.1016%2FS0092-8674%2800%2980191-9&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">
Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.5671-9&rft.date=1996&rft_id=info:doi/10.1074/jbc.271.10.5671&rft_id=info:pmid/8621431&rft.aulast=Hay&rft.aufirst=JC&rft.au=Hirling, H&rft.au=Scheller, RH&rft_id=https://doi.org/10.1074%2Fjbc.271.10.5671&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">

External links

BET1 human gene location in the UCSC Genome Browser.
BET1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105829 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9382863-5] Zhang T, Wong SH, Tang BL, Xu Y, Peter F, Subramaniam VN, Hong W (Dec 1997). "The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus". J Cell Biol. 139 (5): 1157–68. doi:10.1083/jcb.139.5.1157. PMC 2140212. PMID 9382863.1157-68&rft.date=1997-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140212#id-name=PMC&rft_id=info:pmid/9382863&rft_id=info:doi/10.1083/jcb.139.5.1157&rft.aulast=Zhang&rft.aufirst=T&rft.au=Wong, SH&rft.au=Tang, BL&rft.au=Xu, Y&rft.au=Peter, F&rft.au=Subramaniam, VN&rft.au=Hong, W&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140212&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">

[pmid10449330-6] Waters MG, Pfeffer SR (Nov 1999). "Membrane tethering in intracellular transport". Curr Opin Cell Biol. 11 (4): 453–9. doi:10.1016/S0955-0674(99)80065-9. PMID 10449330.453-9&rft.date=1999-11&rft_id=info:doi/10.1016/S0955-0674(99)80065-9&rft_id=info:pmid/10449330&rft.aulast=Waters&rft.aufirst=MG&rft.au=Pfeffer, SR&rfr_id=info:sid/en.wikipedia.org:BET1" class="Z3988">

[entrez-7] "Entrez Gene: BET1 BET1 homolog (S. cerevisiae)".

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[6]

[7]

[1]

[2]

[3]

[4]

BET1

References

Further reading

External links