Wikipedia

Amiphenazole

Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride,[1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia.[6][7] It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.[8][9]

Amiphenazole
Clinical data
ATC code
  • none
Legal status
Legal status
  • AU: S4 (Prescription only)
Identifiers
  • 5-phenyl-1,3-thiazole-2,4-diamine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.013 Edit this at Wikidata
Chemical and physical data
FormulaC9H9N3S
Molar mass191.25 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)C2=C(N=C(S2)N)N
  • InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) checkY
  • Key:UPOYFZYFGWBUKL-UHFFFAOYSA-N checkY
  (verify)

References

edit
  1. ^ Worlock A (November 1956). "Barbiturate poisoning treated with amiphenazole and bemegride". British Medical Journal. 2 (5001): 1099–101. doi:10.1136/bmj.2.5001.1099. PMC 2035840. PMID 13364395.1099-101&rft.date=1956-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2035840#id-name=PMC&rft_id=info:pmid/13364395&rft_id=info:doi/10.1136/bmj.2.5001.1099&rft.aulast=Worlock&rft.aufirst=A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2035840&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  2. ^ Mears GW (March 1958). "Massive doses of bemegride and amiphenazole in treatment of barbiturate poisoning". British Medical Journal. 1 (5073): 757–8. doi:10.1136/bmj.1.5073.757. PMC 2028148. PMID 13510792.757-8&rft.date=1958-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2028148#id-name=PMC&rft_id=info:pmid/13510792&rft_id=info:doi/10.1136/bmj.1.5073.757&rft.aulast=Mears&rft.aufirst=GW&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2028148&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  3. ^ Dotevall G, Herner B (August 1957). "Treatment of acute primidone poisoning with bemegride and amiphenazole". British Medical Journal. 2 (5042): 451–2. doi:10.1136/bmj.2.5042.451. PMC 1961943. PMID 13446511.451-2&rft.date=1957-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1961943#id-name=PMC&rft_id=info:pmid/13446511&rft_id=info:doi/10.1136/bmj.2.5042.451&rft.aulast=Dotevall&rft.aufirst=G&rft.au=Herner, B&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1961943&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  4. ^ Rowell NR (February 1957). "Treatment of glutethimide poisoning with bemegride and amiphenazole". Lancet. 272 (6965): 407–9. doi:10.1016/s0140-6736(57)90466-x. PMID 13407028.407-9&rft.date=1957-02&rft_id=info:doi/10.1016/s0140-6736(57)90466-x&rft_id=info:pmid/13407028&rft.aulast=Rowell&rft.aufirst=NR&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  5. ^ Little GM (January 1962). "Use of amiphenazole in respiratory failure". British Medical Journal. 1 (5273): 223–6. doi:10.1136/bmj.1.5273.223. PMC 1957266. PMID 14465883.223-6&rft.date=1962-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1957266#id-name=PMC&rft_id=info:pmid/14465883&rft_id=info:doi/10.1136/bmj.1.5273.223&rft.aulast=Little&rft.aufirst=GM&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1957266&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  6. ^ Mckeogh J, Shaw FH (January 1956). "Further experience with amiphenazole and morphine in intractable pain". British Medical Journal. 1 (4959): 142–4. doi:10.1136/bmj.1.4959.142. PMC 1978927. PMID 13276651.142-4&rft.date=1956-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978927#id-name=PMC&rft_id=info:pmid/13276651&rft_id=info:doi/10.1136/bmj.1.4959.142&rft.aulast=Mckeogh&rft.aufirst=J&rft.au=Shaw, FH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978927&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  7. ^ Gershon S, Bruce DW, Orchard N, Shaw FH (August 1958). "Amiphenazole and morphine in production of analgesia". British Medical Journal. 2 (5092): 366–8. doi:10.1136/bmj.2.5092.366. PMC 2025982. PMID 13560868.366-8&rft.date=1958-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025982#id-name=PMC&rft_id=info:pmid/13560868&rft_id=info:doi/10.1136/bmj.2.5092.366&rft.aulast=Gershon&rft.aufirst=S&rft.au=Bruce, DW&rft.au=Orchard, N&rft.au=Shaw, FH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025982&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  8. ^ Gairola RL, Gupta PK, Pandley K (January 1980). "Antagonists of morphine-induced respiratory depression. A study in postoperative patients". Anaesthesia. 35 (1): 17–21. doi:10.1111/j.1365-2044.1980.tb03714.x. PMID 6994518. S2CID 40955560.17-21&rft.date=1980-01&rft_id=https://api.semanticscholar.org/CorpusID:40955560#id-name=S2CID&rft_id=info:pmid/6994518&rft_id=info:doi/10.1111/j.1365-2044.1980.tb03714.x&rft.aulast=Gairola&rft.aufirst=RL&rft.au=Gupta, PK&rft.au=Pandley, K&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
  9. ^ O'Neill WM (1994). "The cognitive and psychomotor effects of opioid drugs in cancer pain management". Cancer Surveys. 21: 67–84. PMID 8565000.67-84&rft.date=1994&rft_id=info:pmid/8565000&rft.aulast=O'Neill&rft.aufirst=WM&rfr_id=info:sid/en.wikipedia.org:Amiphenazole" class="Z3988">
 

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