Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| Aldos-2-ulose dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.110 | ||||||||
| CAS no. | 101920-80-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 1,5-anhydro-D-fructose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one H2O (overall reaction)
- (1a) 1,5-anhydro-D-fructose 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose H2O
- (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one
This enzyme catalyses two of the steps in the anhydrofructose pathway.
References
edit- ^ Yu S, Fiskesund R (September 2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochimica et Biophysica Acta (BBA) - General Subjects. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.1314-22&rft.date=2006-09&rft_id=info:doi/10.1016/j.bbagen.2006.05.007&rft_id=info:pmid/16822618&rft.aulast=Yu&rft.aufirst=S&rft.au=Fiskesund, R&rfr_id=info:sid/en.wikipedia.org:Aldos-2-ulose dehydratase" class="Z3988">
- ^ Yu S (May 2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochimica et Biophysica Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.1–3&rft.pages=63-73&rft.date=2005-05&rft_id=info:doi/10.1016/j.bbagen.2005.01.004&rft_id=info:pmid/15716041&rft.aulast=Yu&rft.aufirst=S&rfr_id=info:sid/en.wikipedia.org:Aldos-2-ulose dehydratase" class="Z3988">
- ^ Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41 (1): 151–154. Bibcode:1996PChem..41..151B. doi:10.1016/0031-9422(95)00587-0.151-154&rft.date=1996&rft_id=info:doi/10.1016/0031-9422(95)00587-0&rft_id=info:bibcode/1996PChem..41..151B&rft.au=Broberg, A.&rft.au=Kenne, L.&rft.au=Pedersén, M.&rfr_id=info:sid/en.wikipedia.org:Aldos-2-ulose dehydratase" class="Z3988">
- ^ Gabriel J, Volc J, Sedmera P, Daniel G, Kubátová E (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Archives of Microbiology. 160 (1): 27–34. doi:10.1007/BF00258142. PMID 8352649. S2CID 5987101.27-34&rft.date=1993&rft_id=https://api.semanticscholar.org/CorpusID:5987101#id-name=S2CID&rft_id=info:pmid/8352649&rft_id=info:doi/10.1007/BF00258142&rft.aulast=Gabriel&rft.aufirst=J&rft.au=Volc, J&rft.au=Sedmera, P&rft.au=Daniel, G&rft.au=Kubátová, E&rft_id=https://link.springer.com/article/10.1007/BF00258142&rfr_id=info:sid/en.wikipedia.org:Aldos-2-ulose dehydratase" class="Z3988">
- ^ Yu S, Refdahl C, Lundt I (May 2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochimica et Biophysica Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.120-9&rft.date=2004-05&rft_id=info:doi/10.1016/j.bbagen.2004.03.004&rft_id=info:pmid/15110094&rft.aulast=Yu&rft.aufirst=S&rft.au=Refdahl, C&rft.au=Lundt, I&rfr_id=info:sid/en.wikipedia.org:Aldos-2-ulose dehydratase" class="Z3988">
External links
edit- Aldos-2-ulose dehydratase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
