Adrenergic release inhibitor

Adrenergic release inhibitors are a class of drugs which inhibit the release of epinephrine (adrenaline) and/or norepinephrine (noradrenaline) from adrenergic nerve terminals and are used as antihypertensives.[1][2] Examples of these agents include bethanidine, bretylium, debrisoquine, guanadrel, guanazodine, guancydine, guanethidine, guanoclor, and guanoxan.[1][2] Most agents of this class are guanidinium compounds and have little capacity to cross the blood–brain barrier.[2]

Guanethidine, an adrenergic release inhibitor.

References

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  1. ^ a b Lukas G (1973). "Metabolism and biochemical pharmacology of guanethidine and related compounds". Drug Metab Rev. 2 (1): 101–16. doi:10.3109/03602537409030007. PMID 4590229.101-16&rft.date=1973&rft_id=info:doi/10.3109/03602537409030007&rft_id=info:pmid/4590229&rft.aulast=Lukas&rft.aufirst=G&rfr_id=info:sid/en.wikipedia.org:Adrenergic release inhibitor" class="Z3988">
  2. ^ a b c Stokes, Gordon S.; Oates, Helen F. (1982). "Blockers of the Neuromuscular Junction as Antihypertensive Agents". Hypertensive Cardiovascular Disease: Pathophysiology and Treatment. Springer Netherlands. pp. 828–833. doi:10.1007/978-94-009-7476-0_51. ISSN 0166-9842.828-833&rft.pub=Springer Netherlands&rft.date=1982&rft_id=info:doi/10.1007/978-94-009-7476-0_51&rft.issn=0166-9842&rft.aulast=Stokes&rft.aufirst=Gordon S.&rft.au=Oates, Helen F.&rfr_id=info:sid/en.wikipedia.org:Adrenergic release inhibitor" class="Z3988">