Cysteine protease ATG4A

ATG4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P82
Identifiers
Aliases	ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
External IDs	OMIM: 300663; MGI: 2147903; HomoloGene: 70873; GeneCards: ATG4A; OMA:ATG4A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	108,154,671 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	141,164,270 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gastrocnemius muscle; ; muscle of thigh; ; rectum; ; islet of Langerhans; ; tibialis anterior muscle; ; anterior pituitary; ; left ventricle; ; deltoid muscle; ; right lung;
	Top expressed in
	bone marrow; ; quadriceps femoris muscle; ; muscle of thigh; ; proximal tubule; ; muscle tissue; ; right kidney; ; skeletal muscle tissue; ; ileum; ; granulocyte; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; cysteine-type endopeptidase activity;
Cellular component	cytoplasm; cytosol;
Biological process	autophagy; protein transport; autophagy of nucleus; C-terminal protein lipidation; protein delipidation; autophagy of mitochondrion; autophagosome assembly; proteolysis; protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	115201
	666468
	ENSG00000101844
	ENSMUSG00000079418
	Q8WYN0
	Q8C9S8
NM_052936; NM_178270; NM_178271; NM_001321287; NM_001321288;
	NM_001321289; NM_001321290
	NM_174875
NP_001308216; NP_001308217; NP_001308218; NP_001308219; NP_443168;
	NP_840054; NP_840055
	NP_777364; NP_001366610; NP_001366611; NP_001366612; NP_001366613
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.^[5]^[6]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101844 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.14053-8&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212108200&rft_id=info:pmid/12473658&rft.aulast=Scherz-Shouval&rft.aufirst=R&rft.au=Sagiv, Y&rft.au=Shorer, H&rft.au=Elazar, Z&rft_id=https://doi.org/10.1074%2Fjbc.M212108200&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
^ ^a ^b "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".

External links

Human ATG4A genome location and ATG4A gene details page in the UCSC Genome Browser.

Scherz-Shouval R, Shvets E, Fass E, et al. (2007). "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4". EMBO J. 26 (7): 1749–60. doi:10.1038/sj.emboj.7601623. PMC 1847657. PMID 17347651.1749-60&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847657#id-name=PMC&rft_id=info:pmid/17347651&rft_id=info:doi/10.1038/sj.emboj.7601623&rft.aulast=Scherz-Shouval&rft.aufirst=R&rft.au=Shvets, E&rft.au=Fass, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847657&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.325-37&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665286#id-name=PMC&rft_id=info:pmid/15772651&rft_id=info:doi/10.1038/nature03440&rft_id=info:bibcode/2005Natur.434..325R&rft.aulast=Ross&rft.aufirst=MT&rft.au=Grafham, DV&rft.au=Coffey, AJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665286&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
Kabeya Y, Mizushima N, Yamamoto A, et al. (2005). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation". J. Cell Sci. 117 (Pt 13): 2805–12. doi:10.1242/jcs.01131. PMID 15169837.2805-12&rft.date=2005&rft_id=info:doi/10.1242/jcs.01131&rft_id=info:pmid/15169837&rft.aulast=Kabeya&rft.aufirst=Y&rft.au=Mizushima, N&rft.au=Yamamoto, A&rft_id=https://doi.org/10.1242%2Fjcs.01131&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101844 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079418 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12473658-5] Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.14053-8&rft.date=2003-04&rft_id=info:doi/10.1074/jbc.M212108200&rft_id=info:pmid/12473658&rft.aulast=Scherz-Shouval&rft.aufirst=R&rft.au=Sagiv, Y&rft.au=Shorer, H&rft.au=Elazar, Z&rft_id=https://doi.org/10.1074%2Fjbc.M212108200&rfr_id=info:sid/en.wikipedia.org:Cysteine protease ATG4A" class="Z3988">

[entrez-6] "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".

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[6]

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Cysteine protease ATG4A

References

External links

Further reading