ACOT7

ACOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQ2
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587; MGI: 1917275; HomoloGene: 15780; GeneCards: ACOT7; OMA:ACOT7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,393,767 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,356,312 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; pars compacta; ; Pons; ; endothelial cell; ; anterior cingulate cortex; ; middle temporal gyrus; ; spinal ganglia;
	Top expressed in
	seminiferous tubule; ; anterior horn of spinal cord; ; medial dorsal nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; Medulla Oblongata; ; nucleus of stria terminalis; ; medial vestibular nucleus; ; perirhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; fatty-acyl-CoA binding; protein homodimerization activity; carboxylic ester hydrolase activity; long-chain fatty acyl-CoA binding; protein binding; hydrolase activity; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; thiolester hydrolase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; extracellular exosome; cytoplasm;
Biological process	medium-chain fatty acid biosynthetic process; medium-chain fatty-acyl-CoA catabolic process; long-chain fatty-acyl-CoA catabolic process; coenzyme A biosynthetic process; palmitic acid biosynthetic process; acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.^[5]^[6]^[7]^[8]

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.1013-9&rft.date=2000-03&rft_id=info:doi/10.1093/oxfordjournals.jbchem.a022544&rft_id=info:pmid/10578051&rft.aulast=Yamada&rft.aufirst=J&rft.au=Kurata, A&rft.au=Hirata, M&rft.au=Taniguchi, T&rft.au=Takama, H&rft.au=Furihata, T&rft.au=Shiratori, K&rft.au=Iida, N&rft.au=Takagi-Sakuma, M&rft.au=Watanabe, T&rft.au=Kurosaki, K&rft.au=Endo, T&rft.au=Suga, T&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.2029-32&rft.date=2005-08&rft_id=info:doi/10.1194/jlr.E500003-JLR200&rft_id=info:pmid/16103133&rft.aulast=Hunt&rft.aufirst=MC&rft.au=Yamada, J&rft.au=Maltais, LJ&rft.au=Wright, MW&rft.au=Podesta, EJ&rft.au=Alexson, SE&rft_id=https://doi.org/10.1194%2Fjlr.E500003-JLR200&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.1855-64&rft.date=2006-08&rft_id=https://api.semanticscholar.org/CorpusID:501610#id-name=S2CID&rft_id=info:pmid/16940157&rft_id=info:doi/10.1096/fj.06-6042com&rft.aulast=Hunt&rft.aufirst=MC&rft.au=Rautanen, A&rft.au=Westin, MA&rft.au=Svensson, LT&rft.au=Alexson, SE&rft_id=https://arrow.dit.ie/scschbioart/11&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
^ ^a ^b "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

External links

Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser.

Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain". Amino Acids. 28 (3): 273–8. doi:10.1007/s00726-005-0181-1. PMID 15731883. S2CID 10678899.273-8&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:10678899#id-name=S2CID&rft_id=info:pmid/15731883&rft_id=info:doi/10.1007/s00726-005-0181-1&rft.au=Yamada J&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Yamada J, Kuramochi Y, Takagi M, et al. (2003). "Human brain acyl-CoA hydrolase isoforms encoded by a single gene". Biochem. Biophys. Res. Commun. 299 (1): 49–56. doi:10.1016/S0006-291X(02)02587-1. PMID 12435388.49-56&rft.date=2003&rft_id=info:doi/10.1016/S0006-291X(02)02587-1&rft_id=info:pmid/12435388&rft.aulast=Yamada&rft.aufirst=J&rft.au=Kuramochi, Y&rft.au=Takagi, M&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Yang JW, Czech T, Yamada J, et al. (2005). "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy". Amino Acids. 27 (3–4): 269–75. doi:10.1007/s00726-004-0138-9. PMID 15592755. S2CID 2832201.3–4&rft.pages=269-75&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:2832201#id-name=S2CID&rft_id=info:pmid/15592755&rft_id=info:doi/10.1007/s00726-004-0138-9&rft.aulast=Yang&rft.aufirst=JW&rft.au=Czech, T&rft.au=Yamada, J&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.315-21&rft.date=2006&rft_id=info:pmid/16710414&rft_id=info:doi/10.1038/nature04727&rft_id=info:bibcode/2006Natur.441..315G&rft.aulast=Gregory&rft.aufirst=SG&rft.au=Barlow, KF&rft.au=McLay, KE&rft_id=https://doi.org/10.1038%2Fnature04727&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.801-14&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:13709685#id-name=S2CID&rft_id=info:pmid/16713569&rft_id=info:doi/10.1016/j.cell.2006.03.032&rft.aulast=Lim&rft.aufirst=J&rft.au=Hao, T&rft.au=Shaw, C&rft_id=https://doi.org/10.1016%2Fj.cell.2006.03.032&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10578051-5] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.1013-9&rft.date=2000-03&rft_id=info:doi/10.1093/oxfordjournals.jbchem.a022544&rft_id=info:pmid/10578051&rft.aulast=Yamada&rft.aufirst=J&rft.au=Kurata, A&rft.au=Hirata, M&rft.au=Taniguchi, T&rft.au=Takama, H&rft.au=Furihata, T&rft.au=Shiratori, K&rft.au=Iida, N&rft.au=Takagi-Sakuma, M&rft.au=Watanabe, T&rft.au=Kurosaki, K&rft.au=Endo, T&rft.au=Suga, T&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.2029-32&rft.date=2005-08&rft_id=info:doi/10.1194/jlr.E500003-JLR200&rft_id=info:pmid/16103133&rft.aulast=Hunt&rft.aufirst=MC&rft.au=Yamada, J&rft.au=Maltais, LJ&rft.au=Wright, MW&rft.au=Podesta, EJ&rft.au=Alexson, SE&rft_id=https://doi.org/10.1194%2Fjlr.E500003-JLR200&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.1855-64&rft.date=2006-08&rft_id=https://api.semanticscholar.org/CorpusID:501610#id-name=S2CID&rft_id=info:pmid/16940157&rft_id=info:doi/10.1096/fj.06-6042com&rft.aulast=Hunt&rft.aufirst=MC&rft.au=Rautanen, A&rft.au=Westin, MA&rft.au=Svensson, LT&rft.au=Alexson, SE&rft_id=https://arrow.dit.ie/scschbioart/11&rfr_id=info:sid/en.wikipedia.org:ACOT7" class="Z3988">

[entrez-8] "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

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[1]

[2]

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ACOT7

References

External links

Further reading