CENTB2

ACAP2
Identifiers
Aliases	ACAP2, CENTB2, CNT-B2, ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
External IDs	OMIM: 607766; MGI: 1925868; HomoloGene: 8182; GeneCards: ACAP2; OMA:ACAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	195,443,044 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	31,020,063 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; bone marrow cells; ; superficial temporal artery; ; trabecular bone; ; human penis; ; Achilles tendon; ; palpebral conjunctiva; ; jejunal mucosa; ; oral cavity; ; mucosa of paranasal sinus;
	Top expressed in
	stroma of bone marrow; ; superior cervical ganglion; ; left lung lobe; ; transitional epithelium of urinary bladder; ; otic vesicle; ; visual cortex; ; primary visual cortex; ; conjunctival fornix; ; hand; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; GTPase activator activity; phosphatidylinositol-3,5-bisphosphate binding;
Cellular component	endosome; endosome membrane; membrane;
Biological process	protein localization to endosome; positive regulation of GTPase activity; cellular response to nerve growth factor stimulus; endocytic recycling;
	Sources:Amigo / QuickGO
Orthologs
	23527
	78618
	ENSG00000114331
	ENSMUSG00000049076
	Q15057
	Q6ZQK5
	NM_012287
	NM_030138
	NP_036419
	NP_084414
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ACAP2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114331 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049076 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.489-95&rft.date=2000-12&rft_id=info:doi/10.1016/S0968-0004(00)01644-3&rft_id=info:pmid/11050434&rft.aulast=Jackson&rft.aufirst=TR&rft.au=Kearns, BG&rft.au=Theibert, AB&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
^ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.627-38&rft.date=2000-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185579#id-name=PMC&rft_id=info:pmid/11062263&rft_id=info:doi/10.1083/jcb.151.3.627&rft.aulast=Jackson&rft.aufirst=TR&rft.au=Brown, FD&rft.au=Nie, Z&rft.au=Miura, K&rft.au=Foroni, L&rft.au=Sun, J&rft.au=Hsu, VW&rft.au=Donaldson, JG&rft.au=Randazzo, PA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185579&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
^ "Entrez Gene: CENTB2 centaurin, beta 2".

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.223-9&rft.date=1995&rft_id=info:doi/10.1093/dnares/1.5.223&rft_id=info:pmid/7584044&rft.aulast=Nomura&rft.aufirst=N&rft.au=Nagase, T&rft.au=Miyajima, N&rft_id=https://doi.org/10.1093%2Fdnares%2F1.5.223&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.19-31&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221362#id-name=PMC&rft_id=info:pmid/11001876&rft_id=info:doi/10.1042/0264-6021:3510019&rft.aulast=Dowler&rft.aufirst=S&rft.au=Currie, RA&rft.au=Campbell, DG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1221362&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.94-101&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:7200157#id-name=S2CID&rft_id=info:pmid/15592455&rft_id=info:doi/10.1038/nbt1046&rft.aulast=Rush&rft.aufirst=J&rft.au=Moritz, A&rft.au=Lee, KA&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">

External links

Human ACAP2 genome location and ACAP2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114331 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049076 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050434-5] Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci. 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.489-95&rft.date=2000-12&rft_id=info:doi/10.1016/S0968-0004(00)01644-3&rft_id=info:pmid/11050434&rft.aulast=Jackson&rft.aufirst=TR&rft.au=Kearns, BG&rft.au=Theibert, AB&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">

[pmid11062263-6] Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263.627-38&rft.date=2000-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185579#id-name=PMC&rft_id=info:pmid/11062263&rft_id=info:doi/10.1083/jcb.151.3.627&rft.aulast=Jackson&rft.aufirst=TR&rft.au=Brown, FD&rft.au=Nie, Z&rft.au=Miura, K&rft.au=Foroni, L&rft.au=Sun, J&rft.au=Hsu, VW&rft.au=Donaldson, JG&rft.au=Randazzo, PA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185579&rfr_id=info:sid/en.wikipedia.org:CENTB2" class="Z3988">

[entrez-7] "Entrez Gene: CENTB2 centaurin, beta 2".

[5]

[6]

[7]

[1]

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[3]

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CENTB2

References

Further reading

External links