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AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.[1]
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| ECHA InfoCard | 100.005.785 |
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| Formula | C13H19N |
| Molar mass | 189.302 g·mol−1 |
AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.[1]
References
edit- ^ a b Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A (2008). "Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies". Eur. Neuropsychopharmacol. 18 (12): 871–81. doi:10.1016/j.euroneuro.2008.07.006. PMC 2688716. PMID 18755577.871-81&rft.date=2008&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688716#id-name=PMC&rft_id=info:pmid/18755577&rft_id=info:doi/10.1016/j.euroneuro.2008.07.006&rft.aulast=Matsumoto&rft.aufirst=RR&rft.au=Shaikh, J&rft.au=Wilson, LL&rft.au=Vedam, S&rft.au=Coop, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688716&rfr_id=info:sid/en.wikipedia.org:AC927" class="Z3988">