ABT-670

ABT-670
Identifiers
	IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide;
CAS Number	630119-43-6 ;
PubChem CID	16094676;
ChemSpider	17252978 ;
UNII	4L6071XH2J;
ChEMBL	ChEMBL219182 ;
CompTox Dashboard (EPA)	DTXSID30212235 ;
Chemical and physical data
Formula	C19H23N3O2
Molar mass	325.412 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][n ]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C;
	InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) ; Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N ;
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ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D₄ subtype, which was developed as a possible treatment for erectile dysfunction,^[1] although its current uses are limited to scientific research.^[2]

References

^ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–65. doi:10.1021/jm060662k. PMID 17149874.7450-65&rft.date=2006-12&rft_id=info:doi/10.1021/jm060662k&rft_id=info:pmid/17149874&rft.aulast=Patel&rft.aufirst=MV&rft.au=Kolasa, T&rft.au=Mortell, K&rft.au=Matulenko, MA&rft.au=Hakeem, AA&rft.au=Rohde, JJ&rft.au=Nelson, SL&rft.au=Cowart, MD&rft.au=Nakane, M&rft.au=Miller, LN&rft.au=Uchic, ME&rft.au=Terranova, MA&rft.au=El-Kouhen, OF&rft.au=Donnelly-Roberts, DL&rft.au=Namovic, MT&rft.au=Hollingsworth, PR&rft.au=Chang, R&rft.au=Martino, BR&rft.au=Wetter, JM&rft.au=Marsh, KC&rft.au=Martin, R&rft.au=Darbyshire, JF&rft.au=Gintant, G&rft.au=Hsieh, GC&rft.au=Moreland, RB&rft.au=Sullivan, JP&rft.au=Brioni, JD&rft.au=Stewart, AO&rfr_id=info:sid/en.wikipedia.org:ABT-670" class="Z3988">
^ Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection". Neuroscience Letters. 465 (3): 242–7. doi:10.1016/j.neulet.2009.08.078. PMID 19733217. S2CID 27767274.242-7&rft.date=2009-11&rft_id=https://api.semanticscholar.org/CorpusID:27767274#id-name=S2CID&rft_id=info:pmid/19733217&rft_id=info:doi/10.1016/j.neulet.2009.08.078&rft.aulast=Richards&rft.aufirst=N&rft.au=Wayman, C&rft.au=Allers, KA&rfr_id=info:sid/en.wikipedia.org:ABT-670" class="Z3988">

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[1] Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–65. doi:10.1021/jm060662k. PMID 17149874.7450-65&rft.date=2006-12&rft_id=info:doi/10.1021/jm060662k&rft_id=info:pmid/17149874&rft.aulast=Patel&rft.aufirst=MV&rft.au=Kolasa, T&rft.au=Mortell, K&rft.au=Matulenko, MA&rft.au=Hakeem, AA&rft.au=Rohde, JJ&rft.au=Nelson, SL&rft.au=Cowart, MD&rft.au=Nakane, M&rft.au=Miller, LN&rft.au=Uchic, ME&rft.au=Terranova, MA&rft.au=El-Kouhen, OF&rft.au=Donnelly-Roberts, DL&rft.au=Namovic, MT&rft.au=Hollingsworth, PR&rft.au=Chang, R&rft.au=Martino, BR&rft.au=Wetter, JM&rft.au=Marsh, KC&rft.au=Martin, R&rft.au=Darbyshire, JF&rft.au=Gintant, G&rft.au=Hsieh, GC&rft.au=Moreland, RB&rft.au=Sullivan, JP&rft.au=Brioni, JD&rft.au=Stewart, AO&rfr_id=info:sid/en.wikipedia.org:ABT-670" class="Z3988">

[pmid19733217-2] Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection". Neuroscience Letters. 465 (3): 242–7. doi:10.1016/j.neulet.2009.08.078. PMID 19733217. S2CID 27767274.242-7&rft.date=2009-11&rft_id=https://api.semanticscholar.org/CorpusID:27767274#id-name=S2CID&rft_id=info:pmid/19733217&rft_id=info:doi/10.1016/j.neulet.2009.08.078&rft.aulast=Richards&rft.aufirst=N&rft.au=Wayman, C&rft.au=Allers, KA&rfr_id=info:sid/en.wikipedia.org:ABT-670" class="Z3988">

[1]

[2]

Identifiers

IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide
CAS Number	630119-43-6^N
PubChem CID	16094676
ChemSpider	17252978^Y
UNII	4L6071XH2J
ChEMBL	ChEMBL219182^Y
CompTox Dashboard (EPA)	DTXSID30212235
Chemical and physical data
Formula	C₁₉H₂₃N₃O₂
Molar mass	325.412 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [O-][n ]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C
InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)^Y Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

ABT-670

See also

References