The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.
The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[5] It is expressed in a wide range of human tissues.[6]
Function
editThe protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[7]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000081760 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029482 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
- ^ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
- ^ Aguiló F, Camarero N, Relat J, Marrero PF, Haro D (March 2010). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma" (PDF). The Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. PMID 20102333. S2CID 1043396.255-264&rft.date=2010-03&rft_id=https://api.semanticscholar.org/CorpusID:1043396#id-name=S2CID&rft_id=info:pmid/20102333&rft_id=info:doi/10.1042/bj20090851&rft.aulast=Aguiló&rft.aufirst=F&rft.au=Camarero, N&rft.au=Relat, J&rft.au=Marrero, PF&rft.au=Haro, D&rft_id=https://hal.science/hal-00479205/file/PEER_stage2_10.1042%252FBJ20090851.pdf&rfr_id=info:sid/en.wikipedia.org:AACS (gene)" class="Z3988">
 | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |