7-Carboxy-7-deazaguanine synthase (EC 4.3.99.3, 7-carboxy-7-carbaguanine synthase, queE (gene)) is an enzyme with systematic name 6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase.[1] This enzyme catalyses the following chemical reaction
| 7-carboxy-7-deazaguanine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.3.99.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 6-carboxy-5,6,7,8-tetrahydropterin 7-carboxy-7-carbaguanine NH3
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.
References
edit- ^ McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V (May 2009). "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ0 from guanosine 5′-triphosphate in four steps". Biochemistry. 48 (18): 3847–52. doi:10.1021/bi900400e. PMC 2693876. PMID 19354300.3847-52&rft.date=2009-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693876#id-name=PMC&rft_id=info:pmid/19354300&rft_id=info:doi/10.1021/bi900400e&rft.aulast=McCarty&rft.aufirst=RM&rft.au=Somogyi, A&rft.au=Lin, G&rft.au=Jacobsen, NE&rft.au=Bandarian, V&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693876&rfr_id=info:sid/en.wikipedia.org:7-carboxy-7-deazaguanine synthase" class="Z3988">
External links
edit- 7-carboxy-7-deazaguanine synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
