Linoleate 8R-lipoxygenase (EC 1.13.11.60, linoleic acid 8R-dioxygenase, 5,8-LDS (bifunctional enzyme), 7,8-LDS (bifunctional enzyme), 5,8-linoleate diol synthase (bifunctional enzyme), 7,8-linoleate diol synthase (bifunctional enzyme), PpoA) is an enzyme with systematic name linoleate:oxygen (8R)-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Linoleate 8R-lipoxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.13.11.60 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- linoleate O2 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
Linoleate 8R-lipoxygenase contains heme.
References
edit- ^ Brodhun F, Göbel C, Hornung E, Feussner I (May 2009). "Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450". The Journal of Biological Chemistry. 284 (18): 11792–805. doi:10.1074/jbc.M809152200. PMC 2673248. PMID 19286665.11792-805&rft.date=2009-05&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673248#id-name=PMC&rft_id=info:pmid/19286665&rft_id=info:doi/10.1074/jbc.M809152200&rft.aulast=Brodhun&rft.aufirst=F&rft.au=Göbel, C&rft.au=Hornung, E&rft.au=Feussner, I&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673248&rfr_id=info:sid/en.wikipedia.org:Linoleate 8R-lipoxygenase" class="Z3988">
- ^ Hamberg M, Zhang LY, Brodowsky ID, Oliw EH (February 1994). "Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions". Archives of Biochemistry and Biophysics. 309 (1): 77–80. doi:10.1006/abbi.1994.1087. PMID 8117115.77-80&rft.date=1994-02&rft_id=info:doi/10.1006/abbi.1994.1087&rft_id=info:pmid/8117115&rft.aulast=Hamberg&rft.aufirst=M&rft.au=Zhang, LY&rft.au=Brodowsky, ID&rft.au=Oliw, EH&rfr_id=info:sid/en.wikipedia.org:Linoleate 8R-lipoxygenase" class="Z3988">
- ^ Garscha U, Oliw E (September 2008). "Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase". Biochemical and Biophysical Research Communications. 373 (4): 579–83. doi:10.1016/j.bbrc.2008.06.060. PMID 18586008.579-83&rft.date=2008-09&rft_id=info:doi/10.1016/j.bbrc.2008.06.060&rft_id=info:pmid/18586008&rft.aulast=Garscha&rft.aufirst=U&rft.au=Oliw, E&rfr_id=info:sid/en.wikipedia.org:Linoleate 8R-lipoxygenase" class="Z3988">
- ^ Su C, Oliw EH (June 1996). "Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein". The Journal of Biological Chemistry. 271 (24): 14112–8. doi:10.1074/jbc.271.24.14112. PMID 8662736.14112-8&rft.date=1996-06&rft_id=info:doi/10.1074/jbc.271.24.14112&rft_id=info:pmid/8662736&rft.aulast=Su&rft.aufirst=C&rft.au=Oliw, EH&rft_id=https://doi.org/10.1074%2Fjbc.271.24.14112&rfr_id=info:sid/en.wikipedia.org:Linoleate 8R-lipoxygenase" class="Z3988">
External links
edit- Linoleate 8R-lipoxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
