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5-HT1F receptor

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5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.[5][6][7][8][9]

HTR1F
Identifiers
AliasesHTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F receptor, 5-hydroxytryptamine receptor 1F
External IDsOMIM: 182134; MGI: 99842; HomoloGene: 37361; GeneCards: HTR1F; OMA:HTR1F - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3355

15557

Ensembl

ENSG00000179097

ENSMUSG00000050783

UniProt

P30939

Q02284

RefSeq (mRNA)

NM_000866
NM_001322208
NM_001322209
NM_001322210

NM_008310

RefSeq (protein)

NP_000857
NP_001309137
NP_001309138
NP_001309139

NP_032336

Location (UCSC)Chr 3: 87.79 – 87.99 MbChr 16: 64.75 – 64.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Agonists

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  • 5-n-Butyryloxy-DMT:[10] >60-fold selectivity versus 5-HT1E receptor
  • BRL-54443 - mixed 5-HT1E/1F agonist
  • Eletriptan - mixed 5-HT1B/1D/1E/1F/2B/7 agonist
  • LY-334,370[11] - as well as related benzamides[12]
  • LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
  • Naratriptan - mixed 5-HT1B/1D/1F agonist
  • Lasmiditan - selective 5-HT1F agonist, a first-in-class ditan molecule

Antagonists

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MLS000756415[13]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179097 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050783 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
  6. ^ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.408-12&rft.date=1993-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45671#id-name=PMC&rft_id=info:pmid/8380639&rft_id=info:doi/10.1073/pnas.90.2.408&rft_id=info:bibcode/1993PNAS...90..408A&rft.aulast=Adham&rft.aufirst=N&rft.au=Kao, HT&rft.au=Schecter, LE&rft.au=Bard, J&rft.au=Olsen, M&rft.au=Urquhart, D&rft.au=Durkin, M&rft.au=Hartig, PR&rft.au=Weinshank, RL&rft.au=Branchek, TA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45671&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  7. ^ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.2184-8&rft.date=1993-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46050#id-name=PMC&rft_id=info:pmid/8384716&rft_id=info:doi/10.1073/pnas.90.6.2184&rft_id=info:bibcode/1993PNAS...90.2184L&rft.aulast=Lovenberg&rft.aufirst=TW&rft.au=Erlander, MG&rft.au=Baron, BM&rft.au=Racke, M&rft.au=Slone, AL&rft.au=Siegel, BW&rft.au=Craft, CM&rft.au=Burns, JE&rft.au=Danielson, PE&rft.au=Sutcliffe, JG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46050&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  8. ^ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.133-5&rft.date=1997&rft_id=info:doi/10.3109/09687689709048173&rft_id=info:pmid/9394293&rft.aulast=Erdmann&rft.aufirst=J&rft.au=Shimron-Abarbanell, D&rft.au=Shridhar, V&rft.au=Smith, DI&rft.au=Propping, P&rft.au=Nöthen, MM&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  9. ^ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.415-20&rft.date=1998-06&rft_id=info:doi/10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L&rft_id=info:pmid/9632173&rft.aulast=Maassen VanDenBrink&rft.aufirst=A&rft.au=Vergouwe, MN&rft.au=Ophoff, RA&rft.au=Naylor, SL&rft.au=Dauwerse, HG&rft.au=Saxena, PR&rft.au=Ferrari, MD&rft.au=Frants, RR&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  10. ^ Klein MT, Dukat M, Glennon RA, Teitler M (Jun 2011). "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics. 337 (3): 860–7. doi:10.1124/jpet.111.179606. PMC 3101003. PMID 21422162.860-7&rft.date=2011-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101003#id-name=PMC&rft_id=info:pmid/21422162&rft_id=info:doi/10.1124/jpet.111.179606&rft.aulast=Klein&rft.aufirst=MT&rft.au=Dukat, M&rft.au=Glennon, RA&rft.au=Teitler, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101003&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  11. ^ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (Mar 2005). "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. S2CID 2230855.169-77&rft.date=2005-03&rft_id=https://api.semanticscholar.org/CorpusID:2230855#id-name=S2CID&rft_id=info:pmid/15900510&rft_id=info:doi/10.1007/s00210-005-1035-9&rft.aulast=Wainscott&rft.aufirst=DB&rft.au=Krushinski, JH&rft.au=Audia, JE&rft.au=Schaus, JM&rft.au=Zgombick, JM&rft.au=Lucaites, VL&rft.au=Nelson, DL&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  12. ^ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (Dec 2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.6011-6&rft.date=2004-12&rft_id=info:doi/10.1016/j.bmcl.2004.09.079&rft_id=info:pmid/15546719&rft.aulast=Zhang&rft.aufirst=D&rft.au=Kohlman, D&rft.au=Krushinski, J&rft.au=Liang, S&rft.au=Ying, BP&rft.au=Reilly, JE&rft.au=Dinn, SR&rft.au=Wainscott, DB&rft.au=Nutter, S&rft.au=Gough, W&rft.au=Nelson, DL&rft.au=Schaus, JM&rft.au=Xu, YC&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  13. ^ PudChem: MLS000756415

Further reading

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  • Hoyer D, Hannon JP, Martin GR (Apr 2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacology Biochemistry and Behavior. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546. S2CID 25543069.533-54&rft.date=2002-04&rft_id=https://api.semanticscholar.org/CorpusID:25543069#id-name=S2CID&rft_id=info:pmid/11888546&rft_id=info:doi/10.1016/S0091-3057(01)00746-8&rft.aulast=Hoyer&rft.aufirst=D&rft.au=Hannon, JP&rft.au=Martin, GR&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.2–3&rft.pages=179-212&rft.date=2002&rft_id=info:doi/10.1016/S0163-7258(01)00169-3&rft_id=info:pmid/11916537&rft.aulast=Raymond&rft.aufirst=JR&rft.au=Mukhin, YV&rft.au=Gelasco, A&rft.au=Turner, J&rft.au=Collinsworth, G&rft.au=Gettys, TW&rft.au=Grewal, JS&rft.au=Garnovskaya, MN&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Amlaiky N, Ramboz S, Boschert U, Plassat JL, Hen R (Oct 1992). "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus". The Journal of Biological Chemistry. 267 (28): 19761–4. doi:10.1016/S0021-9258(19)88617-9. PMID 1328180.19761-4&rft.date=1992-10&rft_id=info:doi/10.1016/S0021-9258(19)88617-9&rft_id=info:pmid/1328180&rft.aulast=Amlaiky&rft.aufirst=N&rft.au=Ramboz, S&rft.au=Boschert, U&rft.au=Plassat, JL&rft.au=Hen, R&rft_id=https://doi.org/10.1016%2FS0021-9258%2819%2988617-9&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.408-12&rft.date=1993-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45671#id-name=PMC&rft_id=info:pmid/8380639&rft_id=info:doi/10.1073/pnas.90.2.408&rft_id=info:bibcode/1993PNAS...90..408A&rft.aulast=Adham&rft.aufirst=N&rft.au=Kao, HT&rft.au=Schecter, LE&rft.au=Bard, J&rft.au=Olsen, M&rft.au=Urquhart, D&rft.au=Durkin, M&rft.au=Hartig, PR&rft.au=Weinshank, RL&rft.au=Branchek, TA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45671&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.2184-8&rft.date=1993-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46050#id-name=PMC&rft_id=info:pmid/8384716&rft_id=info:doi/10.1073/pnas.90.6.2184&rft_id=info:bibcode/1993PNAS...90.2184L&rft.aulast=Lovenberg&rft.aufirst=TW&rft.au=Erlander, MG&rft.au=Baron, BM&rft.au=Racke, M&rft.au=Slone, AL&rft.au=Siegel, BW&rft.au=Craft, CM&rft.au=Burns, JE&rft.au=Danielson, PE&rft.au=Sutcliffe, JG&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46050&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.415-20&rft.date=1998-06&rft_id=info:doi/10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L&rft_id=info:pmid/9632173&rft.aulast=Maassen VanDenBrink&rft.aufirst=A&rft.au=Vergouwe, MN&rft.au=Ophoff, RA&rft.au=Naylor, SL&rft.au=Dauwerse, HG&rft.au=Saxena, PR&rft.au=Ferrari, MD&rft.au=Frants, RR&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL (Aug 2004). "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors". The Journal of Biological Chemistry. 279 (33): 34614–23. doi:10.1074/jbc.M404673200. PMID 15190056.34614-23&rft.date=2004-08&rft_id=info:doi/10.1074/jbc.M404673200&rft_id=info:pmid/15190056&rft.aulast=Bhatnagar&rft.aufirst=A&rft.au=Sheffler, DJ&rft.au=Kroeze, WK&rft.au=Compton-Toth, B&rft.au=Roth, BL&rft_id=https://doi.org/10.1074%2Fjbc.M404673200&rfr_id=info:sid/en.wikipedia.org:5-HT1F receptor" class="Z3988">
  • Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kääriäinen H, Kere J (Oct 2005). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLOS Genetics. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMC 1270007. PMID 16254601.
edit
  • "5-HT1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Human HTR1F genome location and HTR1F gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



 

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