In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.7.9) is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction[1][2]
| 4-hydroxybenzoyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.7.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- benzoyl-CoA acceptor H2O 4-hydroxybenzoyl-CoA reduced acceptor
The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.
This enzyme participates in benzoate degradation via coa ligation.
Nomenclature
editThis enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:
- 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
- 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.
References
edit- ^ Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS Lett. 251 (1–2): 237–40. doi:10.1016/0014-5793(89)81461-9. PMID 2753161. S2CID 34285295.1–2&rft.pages=237-40&rft.date=1989&rft_id=https://api.semanticscholar.org/CorpusID:34285295#id-name=S2CID&rft_id=info:pmid/2753161&rft_id=info:doi/10.1016/0014-5793(89)81461-9&rft.aulast=Glockler&rft.aufirst=R&rft.au=Tschech, A&rft.au=Fuchs, G&rft_id=https://doi.org/10.1016%2F0014-5793%2889%2981461-9&rfr_id=info:sid/en.wikipedia.org:4-hydroxybenzoyl-CoA reductase" class="Z3988">
- ^ Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G (August 1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. doi:10.1007/s002030050623. PMID 9683649. S2CID 34536644.120-31&rft.date=1998-08&rft_id=https://api.semanticscholar.org/CorpusID:34536644#id-name=S2CID&rft_id=info:pmid/9683649&rft_id=info:doi/10.1007/s002030050623&rft.aulast=Heider&rft.aufirst=J&rft.au=Boll, M&rft.au=Breese, K&rft.au=Breinig, S&rft.au=Ebenau-Jehle, C&rft.au=Feil, U&rft.au=Gad'on, N&rft.au=Laempe, D&rft.au=Leuthner, B&rft.au=Mohamed, ME&rft.au=Schneider, S&rft.au=Burchhardt, G&rft.au=Fuchs, G&rfr_id=info:sid/en.wikipedia.org:4-hydroxybenzoyl-CoA reductase" class="Z3988">
Further reading
edit- Breese K, Fuchs G (1998). "4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins". Eur. J. Biochem. 251 (3): 916–23. doi:10.1046/j.1432-1327.1998.2510916.x. PMID 9490068.916-23&rft.date=1998&rft_id=info:doi/10.1046/j.1432-1327.1998.2510916.x&rft_id=info:pmid/9490068&rft.aulast=Breese&rft.aufirst=K&rft.au=Fuchs, G&rft_id=https://doi.org/10.1046%2Fj.1432-1327.1998.2510916.x&rfr_id=info:sid/en.wikipedia.org:4-hydroxybenzoyl-CoA reductase" class="Z3988">
- Brackmann R, Fuchs G (1993). "Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species". Eur. J. Biochem. 213 (1): 563–71. doi:10.1111/j.1432-1033.1993.tb17795.x. PMID 8477729.563-71&rft.date=1993&rft_id=info:doi/10.1111/j.1432-1033.1993.tb17795.x&rft_id=info:pmid/8477729&rft.aulast=Brackmann&rft.aufirst=R&rft.au=Fuchs, G&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1993.tb17795.x&rfr_id=info:sid/en.wikipedia.org:4-hydroxybenzoyl-CoA reductase" class="Z3988">
- Heider J, Fuchs G (1997). "Anaerobic metabolism of aromatic compounds" (PDF). Eur. J. Biochem. 243 (3): 577–96. doi:10.1111/j.1432-1033.1997.00577.x. PMID 9057820.577-96&rft.date=1997&rft_id=info:doi/10.1111/j.1432-1033.1997.00577.x&rft_id=info:pmid/9057820&rft.aulast=Heider&rft.aufirst=J&rft.au=Fuchs, G&rft_id=http://www.as.ysu.edu/~crcooper/aromatic%20review.pdf&rfr_id=info:sid/en.wikipedia.org:4-hydroxybenzoyl-CoA reductase" class="Z3988">
