DNA-3-methyladenine glycosylase I (EC 3.2.2.20, deoxyribonucleate 3-methyladenine glycosidase I, 3-methyladenine DNA glycosylase I, DNA-3-methyladenine glycosidase I) is an enzyme with systematic name alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine).[1][2][3] This enzyme catalyses the following chemical reaction
| DNA-3-methyladenine glycosylase I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.2.20 | ||||||||
| CAS no. | 89287-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Hydrolysis of alkylated DNA, releasing 3-methyladenine
This enzyme is involved in the removal of alkylated bases from DNA in Escherichia coli.
References
edit- ^ Evensen G, Seeberg E (April 1982). "Adaptation to alkylation resistance involves the induction of a DNA glycosylase". Nature. 296 (5859): 773–5. Bibcode:1982Natur.296..773E. doi:10.1038/296773a0. PMID 7040984. S2CID 4318955.773-5&rft.date=1982-04&rft_id=info:doi/10.1038/296773a0&rft_id=https://api.semanticscholar.org/CorpusID:4318955#id-name=S2CID&rft_id=info:pmid/7040984&rft_id=info:bibcode/1982Natur.296..773E&rft.aulast=Evensen&rft.aufirst=G&rft.au=Seeberg, E&rfr_id=info:sid/en.wikipedia.org:DNA-3-methyladenine glycosylase I" class="Z3988">
- ^ Karran P, Hjelmgren T, Lindahl T (April 1982). "Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents". Nature. 296 (5859): 770–3. Bibcode:1982Natur.296..770K. doi:10.1038/296770a0. PMID 7040983. S2CID 4367726.770-3&rft.date=1982-04&rft_id=info:doi/10.1038/296770a0&rft_id=https://api.semanticscholar.org/CorpusID:4367726#id-name=S2CID&rft_id=info:pmid/7040983&rft_id=info:bibcode/1982Natur.296..770K&rft.aulast=Karran&rft.aufirst=P&rft.au=Hjelmgren, T&rft.au=Lindahl, T&rfr_id=info:sid/en.wikipedia.org:DNA-3-methyladenine glycosylase I" class="Z3988">
- ^ Thomas L, Yang CH, Goldthwait DA (March 1982). "Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine". Biochemistry. 21 (6): 1162–9. doi:10.1021/bi00535a009. PMID 7041972.1162-9&rft.date=1982-03&rft_id=info:doi/10.1021/bi00535a009&rft_id=info:pmid/7041972&rft.aulast=Thomas&rft.aufirst=L&rft.au=Yang, CH&rft.au=Goldthwait, DA&rfr_id=info:sid/en.wikipedia.org:DNA-3-methyladenine glycosylase I" class="Z3988">
External links
edit- DNA-3-methyladenine glycosylase I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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