In enzymology, a 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC 1.1.1.178) is an enzyme that catalyzes the chemical reaction
| 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.178 | ||||||||
| CAS no. | 52227-66-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA NAD 2-methylacetoacetyl-CoA NADH H
Thus, the two substrates of this enzyme are (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA and NAD , whereas its 3 products are 2-methylacetoacetyl-CoA, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD oxidoreductase. Other names in common use include 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, and 2-methyl-3-hydroxy-butyryl CoA dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.
Structural studies
editAs of 20 January 2010, 6 structure have been solved for this class of enzymes, with the PDB accession code 1E3S, 1E3W, 1E6W, 1SO8, 1U7T, 2O23.
References
edit- Conrad RS, Massey LK, Sokatch JR (1974). "D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida". J. Bacteriol. 118 (1): 103–11. doi:10.1128/JB.118.1.103-111.1974. PMC 246645. PMID 4150713.103-11&rft.date=1974&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC246645#id-name=PMC&rft_id=info:pmid/4150713&rft_id=info:doi/10.1128/JB.118.1.103-111.1974&rft.aulast=Conrad&rft.aufirst=RS&rft.au=Massey, LK&rft.au=Sokatch, JR&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC246645&rfr_id=info:sid/en.wikipedia.org:3-hydroxy-2-methylbutyryl-CoA dehydrogenase" class="Z3988">
