In enzymology, a 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:
| 3-dehydro-L-gulonate 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.130 | ||||||||
| CAS no. | 37250-61-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- 3-dehydro-L-gulonate NAD(P) (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate NAD(P)H H
The 3 substrates of this enzyme are 3-dehydro-L-gulonate, NAD , and NADP , whereas its 4 products are (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate, NADH, NADPH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P) 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
edit- Volk WA, Larsen JL (1962). "beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid". J. Biol. Chem. 237 (8): 2454–7. doi:10.1016/S0021-9258(19)73773-9. PMID 13926592.2454-7&rft.date=1962&rft_id=info:doi/10.1016/S0021-9258(19)73773-9&rft_id=info:pmid/13926592&rft.aulast=Volk&rft.aufirst=WA&rft.au=Larsen, JL&rft_id=https://doi.org/10.1016%2FS0021-9258%2819%2973773-9&rfr_id=info:sid/en.wikipedia.org:3-dehydro-L-gulonate 2-dehydrogenase" class="Z3988">
