In enzymology, a 2-oxoadipate reductase (EC 1.1.1.172) is an enzyme that catalyzes the chemical reaction
| 2-oxoadipate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.172 | ||||||||
| CAS no. | 61116-21-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- 2-hydroxyadipate NAD 2-oxoadipate NADH H
Thus, the two substrates of this enzyme are 2-hydroxyadipate and NAD , whereas its 3 products are 2-oxoadipate, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 2-hydroxyadipate:NAD 2-oxidoreductase. Other names in common use include 2-ketoadipate reductase, alpha-ketoadipate reductase, and 2-ketoadipate reductase.
References
edit- Suda T, Robinson JC, Fjellstedt TA (1976). "Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta". Arch. Biochem. Biophys. 176 (2): 610–20. doi:10.1016/0003-9861(76)90205-8. PMID 185965.610-20&rft.date=1976&rft_id=info:doi/10.1016/0003-9861(76)90205-8&rft_id=info:pmid/185965&rft.aulast=Suda&rft.aufirst=T&rft.au=Robinson, JC&rft.au=Fjellstedt, TA&rfr_id=info:sid/en.wikipedia.org:2-oxoadipate reductase" class="Z3988">
