The enzyme 2-hydroxypropyl-CoM lyase (EC 4.4.1.23, epoxyalkane:coenzyme M transferase, epoxyalkane:CoM transferase, epoxyalkane:2-mercaptoethanesulfonate transferase, coenzyme M-epoxyalkane ligase, epoxyalkyl:CoM transferase, epoxypropane:coenzyme M transferase, epoxypropyl:CoM transferase, EaCoMT, 2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming), (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing, (R)-1,2-epoxypropane-forming)) is an enzyme with systematic name (R)-[or (S)]-2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming).[1][2][3] This enzyme catalyses the following reaction:
| 2-hydroxypropyl-CoM lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.4.1.23 | ||||||||
| CAS no. | 244301-07-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) (R)-2-hydroxypropyl-CoM (R)-1,2-epoxypropane HS-CoM
- (2) (S)-2-hydroxypropyl-CoM (S)-1,2-epoxypropane HS-CoM
This enzyme requires zinc.
References
edit- ^ Allen JR, Clark DD, Krum JG, Ensign SA (July 1999). "A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation". Proceedings of the National Academy of Sciences of the United States of America. 96 (15): 8432–7. Bibcode:1999PNAS...96.8432A. doi:10.1073/pnas.96.15.8432. PMC 17533. PMID 10411892.8432-7&rft.date=1999-07&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17533#id-name=PMC&rft_id=info:pmid/10411892&rft_id=info:doi/10.1073/pnas.96.15.8432&rft_id=info:bibcode/1999PNAS...96.8432A&rft.aulast=Allen&rft.aufirst=JR&rft.au=Clark, DD&rft.au=Krum, JG&rft.au=Ensign, SA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17533&rfr_id=info:sid/en.wikipedia.org:2-hydroxypropyl-CoM lyase" class="Z3988">
- ^ Krum JG, Ellsworth H, Sargeant RR, Rich G, Ensign SA (April 2002). "Kinetic and microcalorimetric analysis of substrate and cofactor interactions in epoxyalkane:CoM transferase, a zinc-dependent epoxidase". Biochemistry. 41 (15): 5005–14. doi:10.1021/bi0255221. PMID 11939797.5005-14&rft.date=2002-04&rft_id=info:doi/10.1021/bi0255221&rft_id=info:pmid/11939797&rft.aulast=Krum&rft.aufirst=JG&rft.au=Ellsworth, H&rft.au=Sargeant, RR&rft.au=Rich, G&rft.au=Ensign, SA&rfr_id=info:sid/en.wikipedia.org:2-hydroxypropyl-CoM lyase" class="Z3988">
- ^ Coleman NV, Spain JC (September 2003). "Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of mycobacterium strain JS60". Journal of Bacteriology. 185 (18): 5536–45. doi:10.1128/jb.185.18.5536-5545.2003. PMC 193758. PMID 12949106.5536-45&rft.date=2003-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193758#id-name=PMC&rft_id=info:pmid/12949106&rft_id=info:doi/10.1128/jb.185.18.5536-5545.2003&rft.aulast=Coleman&rft.aufirst=NV&rft.au=Spain, JC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193758&rfr_id=info:sid/en.wikipedia.org:2-hydroxypropyl-CoM lyase" class="Z3988">
External links
edit- 2-hydroxypropyl-CoM lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
