In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction
| 2-coumarate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.11 | ||||||||
| CAS no. | 37251-10-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- 3-(2-hydroxyphenyl)propanoate NAD 2-coumarate NADH H
Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD , whereas its 3 products are 2-coumarate, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD oxidoreductase. This enzyme participates in phenylalanine metabolism.
References
edit- Levy CC, Weinstein GD (December 1964). "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry. 3 (12): 1944–7. doi:10.1021/bi00900a027. PMID 14269315.1944-7&rft.date=1964-12&rft_id=info:doi/10.1021/bi00900a027&rft_id=info:pmid/14269315&rft.aulast=Levy&rft.aufirst=CC&rft.au=Weinstein, GD&rfr_id=info:sid/en.wikipedia.org:2-Coumarate reductase" class="Z3988">
