In enzymology, a 2-alkenal reductase (EC 1.3.1.74) is an enzyme that catalyzes the chemical reaction
| 2-alkenal reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Leukotriene B4 12-hydroxydehydrogenase (NADP-dependent) dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.1.74 | ||||||||
| CAS no. | 9032-20-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- n-alkanal NAD(P) alk-2-enal NAD(P)H H
The 3 substrates of this enzyme are n-alkanal, NAD , and NADP , whereas its 4 products are alk-2-enal, NADH, NADPH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P) 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.
Structural studies
editAs of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.
References
edit- Mano J, Torii Y, Hayashi S-I, et al. (2002). "The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes". Plant Cell Physiol. 43 (12): 1445–55. doi:10.1093/pcp/pcf187. PMID 12514241.1445-55&rft.date=2002&rft_id=info:doi/10.1093/pcp/pcf187&rft_id=info:pmid/12514241&rft.aulast=Mano&rft.aufirst=J&rft.au=Torii, Y&rft.au=Hayashi S-I&rft_id=https://doi.org/10.1093%2Fpcp%2Fpcf187&rfr_id=info:sid/en.wikipedia.org:2-alkenal reductase" class="Z3988">
- Dick RA, Kwak MK, Sutter TR, Kensler TW (2001). "Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase". J. Biol. Chem. 276 (44): 40803–10. doi:10.1074/jbc.M105487200. PMID 11524419.40803-10&rft.date=2001&rft_id=info:doi/10.1074/jbc.M105487200&rft_id=info:pmid/11524419&rft.aulast=Dick&rft.aufirst=RA&rft.au=Kwak, MK&rft.au=Sutter, TR&rft.au=Kensler, TW&rft_id=https://doi.org/10.1074%2Fjbc.M105487200&rfr_id=info:sid/en.wikipedia.org:2-alkenal reductase" class="Z3988">
