1-Indanone

1-Indanone is the organic compound with the formula C₆H₄(CH₂)₂CO. It is one of two isomeric benzocyclopentanones, the other being 2-indanone. It is a colorless solid. 1-Indanone is a substrate for the enzyme indanol dehydrogenase.

1-Indanone

Names
Preferred IUPAC name 2,3-Dihydro-1H-inden-1-one
Other names α-Hydroindone
Identifiers
CAS Number	83-33-0
3D model (JSmol)	Interactive image
Beilstein Reference	507957
ChEBI	CHEBI:17404
ChemSpider	6479
ECHA InfoCard	100.001.337
EC Number	201-470-1
Gmelin Reference	142414
KEGG	C01504
PubChem CID	6735
UNII	V7021Y717I
CompTox Dashboard (EPA)	DTXSID1058892
InChI InChI=1S/C9H8O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4H,5-6H2 Key: QNXSIUBBGPHDDE-UHFFFAOYSA-N
SMILES C1CC(=O)C2=CC=CC=C21
Properties
Chemical formula	C9H8O
Molar mass	132.162 g·mol−1
Appearance	Colorless solid
Melting point	38–42 °C (100–108 °F; 311–315 K)
Boiling point	243–245 °C (469–473 °F; 516–518 K)
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302
Precautionary statements	P261, P264, P270, P271, P280, P301 P312, P302 P352, P304 P340, P305 P351 P338, P312, P321, P330, P332 P313, P337 P313, P362, P403 P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Preparation

It is prepared by oxidation of indane or indene. It can also be prepared by cyclization of phenylpropionic acid.

Uses

1-Indanone is an intermediate in the synthesis of a variety of pharmaceutical drugs including 2-aminoindane (using beta-keto-oxime formation with isoamylnitrite followed by reduction), drinidene, pirandamine, and pyrophendane.