In enzymology, a 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (EC 1.3.1.25) is an enzyme that catalyzes the chemical reaction
| 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.25 | ||||||||
| CAS no. | 60496-16-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate NAD catechol CO2 NADH H
Thus, the two substrates of this enzyme are (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate and NAD , whereas its 4 products are catechol, CO2, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD oxidoreductase (decarboxylating). Other names in common use include 3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase, dihydrodihydroxybenzoate dehydrogenase, DHBDH, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase, 2-hydro-1,2-dihydroxybenzoate dehydrogenase, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD , oxidoreductase, and dihydrodihydroxybenzoate dehydrogenase. This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation.
References
edit- Reiner AM (1972). "Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD ) oxidoreductase (decarboxylating)". J. Biol. Chem. 247 (16): 4960–5. PMID 4341530.4960-5&rft.date=1972&rft_id=info:pmid/4341530&rft.au=Reiner AM&rfr_id=info:sid/en.wikipedia.org:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase" class="Z3988">
- Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S (1992). "cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily". Eur. J. Biochem. 204 (1): 113–20. doi:10.1111/j.1432-1033.1992.tb16612.x. PMID 1740120.113-20&rft.date=1992&rft_id=info:doi/10.1111/j.1432-1033.1992.tb16612.x&rft_id=info:pmid/1740120&rft.aulast=Neidle&rft.aufirst=E&rft.au=Hartnett, C&rft.au=Ornston, LN&rft.au=Bairoch, A&rft.au=Rekik, M&rft.au=Harayama, S&rft_id=https://doi.org/10.1111%2Fj.1432-1033.1992.tb16612.x&rfr_id=info:sid/en.wikipedia.org:1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase" class="Z3988">
