(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.13, KDO transferase, waaA (gene), kdtA (gene), Kdo transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2] This enzyme catalyses the following chemical reaction
| (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.99.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- alpha-Kdo-(2->6)-lipid IVA CMP-alpha-Kdo alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA CMP
The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA.
See also
edit- EC 2.4.99.12, lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
References
edit- ^ Belunis CJ, Raetz CR (May 1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". The Journal of Biological Chemistry. 267 (14): 9988–97. PMID 1577828.9988-97&rft.date=1992-05&rft_id=info:pmid/1577828&rft.aulast=Belunis&rft.aufirst=CJ&rft.au=Raetz, CR&rfr_id=info:sid/en.wikipedia.org:(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase" class="Z3988">
- ^ Löbau S, Mamat U, Brabetz W, Brade H (November 1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Molecular Microbiology. 18 (3): 391–9. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.391-9&rft.date=1995-11&rft_id=info:doi/10.1111/j.1365-2958.1995.mmi_18030391.x&rft_id=info:pmid/8748024&rft.aulast=Löbau&rft.aufirst=S&rft.au=Mamat, U&rft.au=Brabetz, W&rft.au=Brade, H&rfr_id=info:sid/en.wikipedia.org:(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase" class="Z3988">
External links
edit- (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
