(Histone-H3)-lysine-36 demethylase (EC 1.14.11.27, JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| (Histone-H3)-lysine-36 demethylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.11.27 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- protein N6,N6-dimethyl-L-lysine 2 2-oxoglutarate 2 O2 protein L-lysine 2 succinate 2 formaldehyde 2 CO2 (overall reaction)
- (1a) protein N6,N6-dimethyl-L-lysine 2-oxoglutarate O2 protein N6-methyl-L-lysine succinate formaldehyde CO2
- (1b) protein N6-methyl-L-lysine 2-oxoglutarate O2 protein L-lysine succinate formaldehyde CO2
(Histone-H3)-lysine-36 demethylase contains iron(II).
References
edit- ^ Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (February 2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature. 439 (7078): 811–6. Bibcode:2006Natur.439..811T. doi:10.1038/nature04433. PMID 16362057.811-6&rft.date=2006-02&rft_id=info:pmid/16362057&rft_id=info:doi/10.1038/nature04433&rft_id=info:bibcode/2006Natur.439..811T&rft.aulast=Tsukada&rft.aufirst=Y&rft.au=Fang, J&rft.au=Erdjument-Bromage, H&rft.au=Warren, ME&rft.au=Borchers, CH&rft.au=Tempst, P&rft.au=Zhang, Y&rfr_id=info:sid/en.wikipedia.org:(Histone-H3)-lysine-36 demethylase" class="Z3988">
External links
edit- (histone-H3)-lysine-36 demethylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
