Scientist

Summary:

Client is seeking a talented and motivated individual with expertise in enzymology and biochemical & biophysical assay development to join the Bioassay & Profiling group to support small molecule drug discovery programs within the Discovery Technologies department in our South San Francisco research site. The successful candidate should possess strong technical expertise & exceptional hands-on laboratory skills, have excellent written and oral communication skills, enjoy working in a fast-paced multi-functional team environment, and keep current with field of expertise, including literature and technology development.

Day to Day Responsibilities:

• Contribute to the assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development and troubleshooting in support of small molecule drug discovery.
• Develop and execute biochemical assays and convert into high-throughput screening (HTS) format to enable HTS campaign and meet project goals.
• Apply sophisticated biochemical and biophysical assay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study.
• Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature.
• Strong data analysis capabilities and able to communicate and present research results and provide scientific and technical support.
• Collaborate with internal cross-functional teams and external partners to enable project progression.
  
  

Preferred Qualifications

• PhD in biophysics, biochemistry, molecular biology, or a related discipline.
• Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies.
• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc.
• Experience with biophysical techniques and instruments used to characterize ligand binding such as Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), etc.
• Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers.
• Expertise in handling, analyzing and visualizing assay data sets and proficient in software platform such as GraphPad Prism.
• Drug discovery research experience in diverse target classes is a plus but not required.
• Detail-oriented and analytical with excellent problem-solving skills.
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
  
  

Top 3 Must Have Skill Sets:

• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc.
• Experience with biophysical techniques and instruments used to characterize ligand binding such as Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), etc.
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
  
  

Compensation:

The pay rate range above is the base hourly pay range that Aditi Consulting reasonably expects to pay someone for this position (compensation may vary outside of this range depending on several factors, including but not limited to, a candidate’s qualifications, skills, competencies, competencies, competencies, competencies, experience, location and end client requirements).

Benefits and Ancillaries:

Medical, dental, vision, PTO benefits and ancillaries may be available for eligible Aditi Consulting employees and vary based on the plan options selected by the employee.

Aditi Consulting LLC uses AI technology to engage candidates during the sourcing process. AI technology is used to gather data only and does not replace human-based decision making in employment decisions.