The enzymology of combinatorial biosynthesis (Q35188415)

7 August 2017

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title

The enzymology of combinatorial biosynthesis (English)

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7 August 2017

Christopher D Reeves

1

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7 August 2017

language of work or name

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1 January 2003

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Critical Reviews in Biotechnology

7 August 2017

published in

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7 August 2017

volume

23

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7 August 2017

issue

2

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7 August 2017

page(s)

95-147

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Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum

7 August 2017

cites work

1 reference

Enzymatic formation of an unnatural C(6)-C(5) aromatic polyketide by plant type III polyketide synthases.

21 January 2018

1 reference

Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum

21 January 2018

1 reference

The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates

21 January 2018

1 reference

The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products

21 January 2018

1 reference

The calicheamicin gene cluster and its iterative type I enediyne PKS

21 January 2018

1 reference

Sequence around the 159 degree region of the Bacillus subtilis genome: the pksX locus spans 33.6 kb.

21 January 2018

1 reference

Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida

21 January 2018

1 reference

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

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A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

21 January 2018

1 reference

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus

21 January 2018

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Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

21 January 2018

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The chalcone synthase superfamily of type III polyketide synthases

21 January 2018

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Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis

21 January 2018

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Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis

21 January 2018

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Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions

21 January 2018

1 reference

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

21 January 2018

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Iterative chain elongation by a pikromycin monomodular polyketide synthase

21 January 2018

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

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Mutational analysis of the C-domain in nonribosomal peptide synthesis

21 January 2018

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Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin

21 January 2018

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Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

21 January 2018

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Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase

21 January 2018

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Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose.

21 January 2018

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Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

21 January 2018

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Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455.

21 January 2018

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Aspergillus has distinct fatty acid synthases for primary and secondary metabolism

21 January 2018

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Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

21 January 2018

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Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae

21 January 2018

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Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase

21 January 2018

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The Mechanism of ACV Synthetase

21 January 2018

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Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

21 January 2018

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The candicidin gene cluster from Streptomyces griseus IMRU 3570.

21 January 2018

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The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

21 January 2018

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Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

21 January 2018

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Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins

21 January 2018

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Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase

21 January 2018

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Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis

21 January 2018

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Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase

21 January 2018

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The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

21 January 2018

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Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis

21 January 2018

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Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit

21 January 2018

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Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine

21 January 2018

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Mechanisms of molecular recognition in the pikromycin polyketide synthase

21 January 2018

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Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.

21 January 2018

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Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

21 January 2018

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Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster

21 January 2018

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The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

21 January 2018

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Microcystin biosynthesis in planktothrix: genes, evolution, and manipulation

21 January 2018

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Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea

21 January 2018

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Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products

21 January 2018

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Genetics and assembly line enzymology of siderophore biosynthesis in bacteria

21 January 2018

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The tylosin-biosynthetic genes of Streptomyces fradiae

21 January 2018

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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

21 January 2018

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The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli

21 January 2018

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Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli

21 January 2018

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Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2).

21 January 2018

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Molecular biology of peptide and polyketide biosynthesis in cyanobacteria.

21 January 2018

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Biosynthesis of natural products on modular peptide synthetases

21 January 2018

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Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

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Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer

21 January 2018

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The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

21 January 2018

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Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules

21 January 2018

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Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins

21 January 2018

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Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis

21 January 2018

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Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics

21 January 2018

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Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis

21 January 2018

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Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

21 January 2018

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Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity

21 January 2018

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Antibiotic biosynthesis: from natural to unnatural compounds

21 January 2018

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A new pathway for polyketide synthesis in microorganisms

21 January 2018

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Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis

21 January 2018

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Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus.

21 January 2018

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New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster

21 January 2018

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Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

21 January 2018

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In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases

21 January 2018

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The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

21 January 2018

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Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.

21 January 2018

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Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family

21 January 2018

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Enniatin synthetase is a monomer with extended structure: evidence for an intramolecular reaction mechanism

21 January 2018

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

21 January 2018

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Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase

21 January 2018

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Formation of unusual sugars: mechanistic studies and biosynthetic applications

21 January 2018

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Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

21 January 2018

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Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50.

21 January 2018

1 reference

Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene

21 January 2018

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Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies

21 January 2018

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The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses

21 January 2018

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Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

21 January 2018

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Genetic Contributions to Understanding Polyketide Synthases

21 January 2018

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Characterization of the biosynthetic gene cluster for the oligosaccharide antibiotic, Evernimicin, in Micromonospora carbonacea var. africana ATCC39149.

21 January 2018

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Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes

21 January 2018

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

21 January 2018

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Microbial polyketide synthases: more and more prolific

21 January 2018

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Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases.

21 January 2018

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Polyketide and non-ribosomal peptide synthases: falling together by coming apart

21 January 2018

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Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis

21 January 2018

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Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

21 January 2018

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Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases

21 January 2018

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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

21 January 2018

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Structural control of polyketide formation in plant-specific polyketide synthases

21 January 2018

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Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase

21 January 2018

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Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase.

21 January 2018

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Structure-guided programming of polyketide chain-length determination in chalcone synthase

21 January 2018

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Structure and mechanism of chalcone synthase-like polyketide synthases

21 January 2018

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Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity

21 January 2018

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Multiple alternate transcripts direct the biosynthesis of microcystin, a cyanobacterial nonribosomal peptide

21 January 2018

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Manipulation of Modular Polyketide Synthases.

21 January 2018

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Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase

21 January 2018

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Harnessing the Biosynthetic Potential of Modular Polyketide Synthases

21 January 2018

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Tolerance and specificity of polyketide synthases

21 January 2018

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Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

21 January 2018

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An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

21 January 2018

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Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants

21 January 2018

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Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species

21 January 2018

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Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

21 January 2018

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Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein

21 January 2018

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C-O bond formation by polyketide synthases

21 January 2018

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A new enzyme superfamily - the phosphopantetheinyl transferases

21 January 2018

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Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

21 January 2018

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Substrate specificity of the loading didomain of the erythromycin polyketide synthase

21 January 2018

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Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster

21 January 2018

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Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

21 January 2018

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Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases

21 January 2018

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Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase

21 January 2018

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Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase

21 January 2018

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

21 January 2018

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Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

21 January 2018

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Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

21 January 2018

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Transformation of acridone synthase to chalcone synthase

21 January 2018

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Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase

21 January 2018

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Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.

21 January 2018

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A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria

21 January 2018

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Protein templates for the biosynthesis of peptide antibiotics

21 January 2018

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Engineering broader specificity into an antibiotic-producing polyketide synthase

21 January 2018

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Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism

21 January 2018

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Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

21 January 2018

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Engineered biosynthesis of novel polyketides

21 January 2018

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Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

21 January 2018

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Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

21 January 2018

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

21 January 2018

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In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase

21 January 2018

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Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

21 January 2018

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Structure alteration of polyketides by recombinant DNA technology in producer organisms--prospects for the generation of novel pharmaceutical drugs

21 January 2018

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Altering the glycosylation pattern of bioactive compounds

21 January 2018

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Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species

21 January 2018

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Engineering anthracycline biosynthesis toward angucyclines

21 January 2018

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Functional analysis of putative beta-ketoacyl:acyl carrier protein synthase and acyltransferase active site motifs in a type II polyketide synthase of Streptomyces glaucescens

21 January 2018

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Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides

21 January 2018

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Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis

21 January 2018

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Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations.

21 January 2018

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Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4'-phosphopantetheinyl transferases AcpS and Sfp.

21 January 2018

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The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

21 January 2018

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Engineering biodiversity with type II polyketide synthase genes

21 January 2018

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Biosynthesis and attachment of novel bacterial polyketide synthase starter units

21 January 2018

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Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone

21 January 2018

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Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes

21 January 2018

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Techniques: Recombinogenic engineering--new options for cloning and manipulating DNA.

21 January 2018

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Nonactin biosynthesis: the initial committed step is the condensation of acetate (malonate) and succinate

21 January 2018

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Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.

21 January 2018

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Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces

21 January 2018

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The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I

21 January 2018

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Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery

21 January 2018

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Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

21 January 2018

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Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

21 January 2018

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The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase

21 January 2018

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Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway

21 January 2018

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Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes

21 January 2018

1 reference

Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.

21 January 2018

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

21 January 2018

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Biosynthesis of polyketides in heterologous hosts

21 January 2018

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A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine

21 January 2018

1 reference

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

21 January 2018

1 reference

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis

21 January 2018

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Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353.

21 January 2018

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The product of dpsC confers starter unit fidelity upon the daunorubicin polyketide synthase of Streptomyces sp. strain C5.

21 January 2018

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Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue

21 January 2018

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

21 January 2018

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Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

21 January 2018

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Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster

21 January 2018

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Biosynthesis of polyketides

21 January 2018

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Type I polyketide biosynthesis in bacteria (part B).

21 January 2018

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Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).

21 January 2018

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Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules

21 January 2018

1 reference

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

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A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.

21 January 2018

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

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Genetically engineered analogs of ascomycin for nerve regeneration

21 January 2018

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Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase

21 January 2018

1 reference

Modification of post-PKS tailoring steps through combinatorial biosynthesis

21 January 2018

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Combinatorial biosynthesis of antimicrobials and other natural products

21 January 2018

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Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

21 January 2018

1 reference

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

21 January 2018

1 reference

Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line

21 January 2018

1 reference

Plant polyketide synthases: a chalcone synthase-type enzyme which performs a condensation reaction with methylmalonyl-CoA in the biosynthesis of C-methylated chalcones

21 January 2018

1 reference

Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase

21 January 2018

1 reference

Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.

21 January 2018

1 reference

Macrotetrolide biosynthesis: a novel type II polyketide synthase

21 January 2018

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Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

21 January 2018

1 reference

Evidence for a monomeric structure of nonribosomal Peptide synthetases

21 January 2018

1 reference

New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

21 January 2018

1 reference

Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca

21 January 2018

1 reference

Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

21 January 2018

1 reference

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

Polyketide biosynthesis: a millennium review

21 January 2018

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Combinatorial biosynthesis of polyketides and nonribosomal peptides

21 January 2018

1 reference

Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes

21 January 2018

1 reference

Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.

21 January 2018

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A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tü22.

21 January 2018

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Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

21 January 2018

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Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

21 January 2018

1 reference

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.

21 January 2018

1 reference

The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures

21 January 2018

1 reference

Prokaryotic diversity--magnitude, dynamics, and controlling factors

21 January 2018

1 reference

Genes and enzymes involved in deoxysugar biosynthesis in bacteria

21 January 2018

1 reference

Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics

21 January 2018

1 reference

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways

21 January 2018

1 reference

Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic

21 January 2018

1 reference

Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor

21 January 2018

1 reference

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

21 January 2018

1 reference

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

21 January 2018

1 reference

Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase

21 January 2018

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Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins

21 January 2018

1 reference

A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

21 January 2018

1 reference

21 January 2018

The nonribosomal code

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Nonactin biosynthesis: the potential nonactin biosynthesis gene cluster contains type II polyketide synthase-like genes

21 January 2018

1 reference

A cluster of genes for the biosynthesis of spinosyns, novel macrolide insect control agents produced by Saccharopolyspora spinosa.

21 January 2018

1 reference

21 January 2018

Taxol biosynthetic genes

1 reference

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

21 January 2018

1 reference

Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone

21 January 2018

1 reference

Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1.

21 January 2018

1 reference

Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1).

21 January 2018

1 reference

Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics

21 January 2018

1 reference

Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

21 January 2018

1 reference

Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase

21 January 2018

1 reference

Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases

21 January 2018

1 reference

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

21 January 2018

1 reference

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

21 January 2018

1 reference

Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus"

21 January 2018

1 reference

A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

1 reference

Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae

21 January 2018

1 reference

Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases

21 January 2018

1 reference

Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

21 January 2018

1 reference

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

21 January 2018

1 reference

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

21 January 2018

1 reference

Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

21 January 2018

1 reference

Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase.

21 January 2018

1 reference

Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases

21 January 2018

1 reference

A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator

21 January 2018

1 reference

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

'Streptomyces nanchangensis', a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters

21 January 2018

1 reference

Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1.

21 January 2018

1 reference

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

Production of ‘hybrid’ antibiotics by genetic engineering

21 January 2018

1 reference

Collinone, a new recombinant angular polyketide antibiotic made by an engineered Streptomyces strain

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.54.239

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.340

The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.181.15.4690-4695.1999

Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.181.10.3155-3163.1999

Identifiers

DOI

10.1080/713609311

1 reference

7 August 2017

1 reference