Aklidinijum bromid

Aklidinijum bromid
Klinički podaci
Prodajno ime	Bretaris Genuair, Eklira Genuair, Tudorza Pressair
Drugs.com	bromide.html Monografija
Način primene	Respiratorno (inhalacija)
Farmakokinetički podaci
Poluvreme eliminacije	2,4 minuta
Izlučivanje	Renalno
Identifikatori
CAS broj	320345-99-1
ATC kod	R03BB05 (WHO)
PubChem	CID 11519741
DrugBank	DB08897
ChemSpider	9694529
ChEBI	CHEBI:65344
ChEMBL	CHEMBL551466
Hemijski podaci
Formula	C26H30BrNO4S2
Molarna masa	564,555
	SMILES [Br-].OC(C(=O)OC1C[N ]2(CCCOC3=CC=CC=C3)CCC1CC2)(C1=CC=CS1)C1=CC=CS1; ;
	InChI InChI=1/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q 1;/p-1 ; Key:XLAKJQPTOJHYDR-UHFFFAOYNA-M ;

Aklidinijum bromid je organsko jedinjenje, koje sadrži 26 atoma ugljenika i ima molekulsku masu od 564,555 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	1
Broj rotacionih veza	10
Particioni koeficijent^[6] (ALogP)	1,0
Rastvorljivost^[7] (logS, log(mol/L))	-7,7
Polarna površina^[8] (PSA, Å²)	155,2

Reference

^ Reid, D. J.; Pham, N. T. (Print 2013). „Emerging Therapeutic Options for the Management of COPD”. Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine. 7: 7—15. PMC 3629926 . PMID 23641160. doi:10.4137/CCRPM.S8140. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Cazzola, M.; Page, C. P.; Matera, M. G. (Epub 2013 Apr 9). „Aclidinium bromide for the treatment of chronic obstructive pulmonary disease”. Expert Opinion on Pharmacotherapy. 14 (9): 1205—1214. PMID 23566013. S2CID 24973904. doi:10.1517/14656566.2013.789021. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Jones, P. (Epub 2013 Apr 2). „Aclidinium bromide twice daily for the treatment of chronic obstructive pulmonary disease: A review”. Advances in Therapy. 30 (4): 354—368. PMID 23553509. S2CID 3530290. doi:10.1007/s12325-013-0019-2. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Aclidinium bromide

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Reid, D. J.; Pham, N. T. (Print 2013). „Emerging Therapeutic Options for the Management of COPD”. Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine. 7: 7—15. PMC 3629926 . PMID 23641160. doi:10.4137/CCRPM.S8140. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Cazzola, M.; Page, C. P.; Matera, M. G. (Epub 2013 Apr 9). „Aclidinium bromide for the treatment of chronic obstructive pulmonary disease”. Expert Opinion on Pharmacotherapy. 14 (9): 1205—1214. PMID 23566013. S2CID 24973904. doi:10.1517/14656566.2013.789021. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Jones, P. (Epub 2013 Apr 2). „Aclidinium bromide twice daily for the treatment of chronic obstructive pulmonary disease: A review”. Advances in Therapy. 30 (4): 354—368. PMID 23553509. S2CID 3530290. doi:10.1007/s12325-013-0019-2. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[7] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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