FLT1

FLT1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
Dynodwyr
Cyfenwau	FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1, vascular endothelial growth factor receptor 1, fms related receptor tyrosine kinase 1
Dynodwyr allanol	OMIM: 165070 HomoloGene: 134179 GeneCards: FLT1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• vascular endothelial growth factor-activated receptor activity; • transferase activity; • nucleotide binding; • protein kinase activity; • placental growth factor-activated receptor activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • growth factor binding; • vascular endothelial growth factor binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • endosome; • focal adhesion; • bilen; • receptor complex; • integral component of plasma membrane; • extracellular region; • extracellular space; • Cellbilen; • actin cytoskeleton;
Prosesau biolegol	• positive regulation of vascular endothelial growth factor receptor signaling pathway; • cell differentiation; • blood vessel morphogenesis; • vascular endothelial growth factor receptor-1 signaling pathway; • positive regulation of MAP kinase activity; • monocyte chemotaxis; • positive regulation of phospholipase C activity; • transmembrane receptor protein tyrosine kinase signaling pathway; • vascular endothelial growth factor signaling pathway; • phosphorylation; • positive regulation of angiogenesis; • positive regulation of phosphatidylinositol 3-kinase activity; • multicellular organism development; • chemotaxis; • protein phosphorylation; • vascular endothelial growth factor receptor signaling pathway; • embryonic morphogenesis; • angiogenesis; • protein autophosphorylation; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cellular response to vascular endothelial growth factor stimulus; • cell migration; • positive regulation of MAPK cascade; • positive regulation of cell population proliferation; • positive regulation of cell migration; • sprouting angiogenesis; • positive regulation of ERK1 and ERK2 cascade; • negative regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	2321
	n/a
	ENSG00000102755
	n/a
	P17948
	n/a
	NM_001159920; NM_001160030; NM_001160031; NM_002019
	n/a
	NP_001153392; NP_001153502; NP_001153503; NP_002010
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLT1 yw FLT1 a elwir hefyd yn Fms related tyrosine kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q12.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLT1.

FLT
FLT-1
VEGFR1
VEGFR-1

Llyfryddiaeth

"Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. ". PLoS One. 2017. PMID 28817576.
"Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population. ". Hypertension. 2017. PMID 28652462.
"Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. ". Nat Genet. 2017. PMID 28628106.
"sFLT-1 inhibits proliferation, migration, and invasion of colorectal cancer SW480 cells through vascular mimicry formation suppression. ". Tumour Biol. 2017. PMID 28468595.
"FLT-1 gene polymorphisms and protein expression profile in rheumatoid arthritis.". PLoS One. 2017. PMID 28323906.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FLT1 - Cronfa NCBI

[1]

[2]