G protein signaling modulator 2 (Q21106186)

Tetratricopeptide repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat family

1 reference

based on heuristic

inferred from protein domain or family

GoLoco motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G-protein alpha-subunit binding

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

protein binding

10 references

8 April 2019

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

GTPase regulator activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

identical protein binding

1 reference

8 April 2019

Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

dynein complex binding

1 reference

8 April 2019

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

protein C-terminus binding

1 reference

8 April 2019

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

protein domain specific binding

1 reference

8 April 2019

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

protein self-association

1 reference

8 April 2019

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

cell component

mitotic spindle pole

spindle pole

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

cell cortex region

cell cortex

Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

8 April 2019

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

RanGTP and CLASP1 cooperate to position the mitotic spindle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Cortical dynein is critical for proper spindle positioning in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

lateral plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

centrosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

protein-containing complex

mitotic spindle organization

biological process

1 reference

8 April 2019

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

G protein-coupled receptor signaling pathway

TAS

1 reference

8 April 2019

Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

maintenance of centrosome location

TAS

1 reference

8 April 2019

LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

regulation of catalytic activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

Ran protein signal transduction

1 reference

8 April 2019

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

regulation of mitotic spindle organization

1 reference

8 April 2019

Cortical dynein is critical for proper spindle positioning in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

positive regulation of protein localization to cell cortex

3 references

8 April 2019

Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

8 April 2019

Cortical dynein is critical for proper spindle positioning in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

positive regulation of spindle assembly

1 reference

8 April 2019

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81274

1 reference

8 April 2019

establishment of mitotic spindle orientation

Tetratricopeptide repeat-containing domain

has part(s)

1 reference

tetratricopeptide repeat

1 reference

GoLoco motif

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016