Proteinska fosfataza 2
Изглед
Proteinska fosfataza 2, katalitička jedinica, alfa izoforma | |
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Identifikatori | |
Simbol | PPP2CA |
Entrez | 5515 |
HUGO | 9299 |
OMIM | 176915 |
RefSeq | NM_002715 |
UniProt | P67775 |
Ostali podaci | |
EC broj | 3.1.3.16 |
Lokus | Hromozom 5 q23-q31 |
Proteinska fosfataza 2, katalitička jedinica, beta izoforma | |
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Identifikatori | |
Simbol | PPP2CB |
Entrez | 5516 |
HUGO | 9300 |
OMIM | 176916 |
RefSeq | NM_001009552 |
UniProt | P62714 |
Ostali podaci | |
EC broj | 3.1.3.16 |
Lokus | Hromozom 8 p12 |
Proteinska fosfataza 2 (PP2), takođe poznata kao PP2A, je enzim koji je kod ljudi kodiran PPP2CA genom.[1] PP2A heterotrimerna proteinska fosfataza, je široko zastupljena i konservirana serin/treoninska fosfataza sa širokom supstratnom specifičnošću i različitim ćelijskim funkcijama. Među PP2A metama su proteini onkogene signalne kaskade, poput Raf, MEK, i AKT.
Reference
[уреди | уреди извор]- ^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (1993). „Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively”. Cytogenet. Cell Genet. 63 (1): 35—41. PMID 8383590. doi:10.1159/000133497.
Literatura
[уреди | уреди извор]- Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y (2006). „Structure of the protein phosphatase 2A holoenzyme”. Cell. 127 (6): 1239—51. PMID 17174897. doi:10.1016/j.cell.2006.11.033.
- Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (2006). „Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins”. Cell. 127 (2): 341—53. PMID 17055435. doi:10.1016/j.cell.2006.09.025.
- Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (2003). „Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites”. Curr. Biol. 13 (16): 1356—64. PMID 12932319. doi:10.1016/S0960-9822(03)00535-9.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- PPP2CA protein, human на US National Library of Medicine Medical Subject Headings (MeSH)