PPADS

PPADS
Names
	IUPAC name 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzene-1,3-disulfonic acid
	Other names PPADS
Identifiers
CAS Number	149017-66-3 ; 192575-19-2 (tetrasodium salt) ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:34941 ;
ChemSpider	20136164;
PubChem CID	6093163; 6532796 (tetrasodium salt);
UNII	L6K2LJ9BJK ;
	InChI InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)/b17-16 ;
	SMILES Oc2c(C=O)c(COP(O)(=O)O)c(/N=N/c1ccc(cc1S(O)(=O)=O)S(O)(=O)=O)nc2C;
Properties
Chemical formula	C14H14N3O12PS2
Molar mass	511.37 g·mol−1
Appearance	Orange solid
Solubility in water	100 mM (tetrasodium salt)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.^[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α₁ adrenergic, muscarinic M₂ and M₃, histamine H₁, and adenosine A₁ receptors.^[3]

References

^ PPADS tetrasodium salt, Santa Cruz Biotechnology
^ Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839. PMID 8306091.
^ Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217 (2–3): 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.

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[1] PPADS tetrasodium salt, Santa Cruz Biotechnology

[Ziganshin-2] Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839. PMID 8306091.

[Lambrecht-3] Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217 (2–3): 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.

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