Kanaka Rajan

Kanaka Rajan
Born	India
Nationality	American
Alma mater	Anna University Brandeis University Columbia University Icahn School of Medicine at Mount Sinai
Known for	Recurrent Neural Network (RNN) models of the brain
Scientific career
Fields	Computational and Theoretical Neuroscience
Institutions	Harvard University

Kanaka Rajan is a computational neuroscientist in the Department of Neurobiology at Harvard Medical School and founding faculty in the Kempner Institute for the Study of Natural and Artificial Intelligence at Harvard University. Rajan trained in engineering, biophysics, and neuroscience, and has pioneered novel methods and models to understand how the brain processes sensory information. Her research seeks to understand how important cognitive functions — such as learning, remembering, and deciding — emerge from the cooperative activity of multi-scale neural processes, and how those processes are affected by various neuropsychiatric disease states. The resulting integrative theories about the brain bridge neurobiology and artificial intelligence.

Early life and education

Rajan was born and raised in India. She completed a Bachelors of Technology (B.Tech.) from the Center for Biotechnology at Anna University in Tamil Nadu, India in 2000, majoring in Industrial Biotechnology and graduating with distinction.

In 2002, Rajan pursued a post-graduate degree in neuroscience at Brandeis University, where she did experimental rotations with Eve Marder and Gina G. Turrigiano, before joining Larry Abbott's laboratory where she completed her master's degree (MA). In 2005 she transferred to the Ph.D. program in Neuroscience at Columbia University when Dr. Abbott moved from Brandeis to Columbia, and began her Ph.D. with Abbott at the Center for Theoretical Neuroscience.

Doctoral research

In Rajan's graduate work, she used mathematical modelling to address neurobiological questions. The main component of her thesis was the development of a theory for how the brain interprets subtle sensory cues within the context of its internal experiential and motivational state to extract unambiguous representations of the external world. This line of work focused on the mathematical analysis of neural networks containing excitatory and inhibitory types to model neurons and their synaptic connections. Her work showed that increasing the widths of the distributions of excitatory and inhibitory synaptic strengths dramatically changes the eigenvalue distributions. In a biological context, these findings suggest that having a variety of cell types with different distributions of synaptic strength would impact network dynamics and that synaptic strength distributions can be measured to probe the characteristics of network dynamics. Electrophysiology and imaging studies in many brain regions have since validated the predictions of this phase transition hypothesis.

To do this work, powerful methods from random matrix theory and statistical mechanics were employed. Rajan's early, influential work with Abbott and Haim Sompolinsky integrated physics methodology into mainstream neuroscience research — initially by creating experimentally verifiable predictions, and today by cementing these tools as an essential component of the data modelling arsenal. Rajan completed her Ph.D. in 2009.

Postdoctoral research

From 2010 to 2018, Rajan worked as a postdoctoral research fellow at Princeton University with theoretical biophysicist William Bialek and neuroscientist David W. Tank. At Princeton, she and her colleagues developed and employed a broad set of tools from physics, engineering, and computer science to build new conceptual frameworks for describing the relationship between cognitive processes and biophysics across many scales of biological organization.

Modelling feature selectivity

In Rajan's postdoctoral work with Bialek, she explored an innovative method for modelling the neural phenomenon of feature selectivity. Feature selectivity is the idea that neurons are tuned to respond to specific and discrete components of the incoming sensory information, and later these individual components are merged to generate an overall perception of the sensory landscape. To understand how the brain might receive complex inputs but detect individual features, Rajan treated the problem like a dimensionality reduction instead of the typical linear model approach. Rajan showed, using quadratic forms as features of a stimulus, that the maximally informative variables can be found without prior assumptions of their characteristics. This approach allows for unbiased estimates of the receptive fields for stimuli.

Recurrent neural network modelling

Rajan then worked with David Tank to show that sequential activation of neurons, a common feature in working memory and decision making, can be demonstrated when starting from neural network models with random connectivity. The process, termed “Partial In-Network Training”, is used as both model and to match real neural data from the posterior parietal cortex during behavior. Rather than feedforward connections, the neural sequences in their model propagate through the network via recurrent synaptic interactions as well as being guided by external inputs. Their modelling highlighted the potential that learning can derive from highly unstructured network architectures. This work uncovered how sensitivity to natural stimuli arises in neurons, how this selectivity influences sensorimotor learning, and how the neural sequences observed in different brain regions arise from minimally plastic, largely disordered circuits – published in Neuron.

Career and research

In June 2018, Rajan became an assistant professor in the Department of Neuroscience and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai. As the Principal Investigator of the Rajan Lab for Brain Research and AI in NY (BRAINY), her work focuses on integrative theories to describe how behavior emerges from the cooperative activity of multi-scale neural processes. To gain insight into fundamental brain processes such as learning, memory, multitasking, or reasoning, Rajan develops theories based on neural network architectures inspired by biology as well as mathematical and computational frameworks that are often used to extract information from neural and behavioral data. These theories use neural network models flexible enough to accommodate various levels of biological detail at the neuronal, synaptic, and circuit levels.

She uses a cross-disciplinary approach that provides critical insights into how neural circuits learn and execute functions, ranging from working memory to decision making, reasoning, and intuition, putting her in a unique position to advance our understanding of how important acts of cognition work.  Her models are based on experimental data (e.g., calcium imaging, electrophysiology, and behavior experiments) and on new and existing mathematical and computational frameworks derived from machine learning and statistical physics. Rajan continues to apply recurrent neural network modelling to behavioral and neural data. In collaboration with Karl Deisseroth and his team at Stanford University, such models revealed that circuit interactions within the lateral habenula, a brain structure implicated in aversion, were encoding experience features to guide the behavioral transition from active to passive coping – work published in Cell.

In 2019, Rajan was one of twelve investigators to receive funding from the National Science Foundation (NSF) though its participation in the White House's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. The same year, she was also awarded an NIH BRAIN Initiative grant (R01) for Theories, Models, and Methods for Analysis of Complex Data from the Brain. Starting in 2020, Rajan became co-lead of the Computational Neuroscience Working Group, part of the National Institutes of Health's Interagency Modeling and Analysis Group (IMAG).

In 2022, Rajan was promoted to Associate Professor with tenure in the Department of Neuroscience and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai.

In 2023, Rajan joined the Department of Neurobiology at Harvard Medical School as a Member of the Faculty and Kempner Institute for the Study of Natural and Artificial Intelligence as founding faculty.

Awards and honors

• CIFAR Azrieli Global Scholar – Brain, Mind & Consciousness Program
• McKnight Scholar Award
• Next Generation Leaders, Allen Institute for Brain Science (2021)
• National Science Foundation (NSF) CAREER Award (2021)
• The Harold & Golden Lamport Basic Research Award (2021)
• Friedman Brain Institute Research Scholars Award from the Dyal Foundation (2020)
• Friedman Brain Institute Research Scholars Award from the DiSabato Family (2019)
• Sloan Research Fellowship in Neuroscience (2019)
• Mindlin Foundation 1Tweet1P Award, Neuroscience meets Graphic Novel (2018)
• Understanding Human Cognition Scholar Award from the James McDonnell Foundation (2016)
• Visiting Research Fellowship, Janelia Research Campus, Howard Hughes Medical Institute (2016)
• Brain and Behavior Foundation (formerly, NARSAD) Young Investigator Award (2015-2017)
• Lectureship, Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University for Methods and Logic in Quantitative Biology (2011-2013)
• Grant from the Organization for Computational Neurosciences (OCNS) (2011)
• Sloan-Swartz Theoretical Neuroscience Postdoctoral Fellowship (2010-2012)
• Pulin Sampat Memorial Teaching Award, Brandeis University (2004)
• Tata Institute of Fundamental Research Junior Research Fellowship (2001-2002)

Select publications

• Perich, Matthew G.; Rajan, Kanaka (2020). "Rethinking brain-wide interactions through multi-region 'network of networks' models". Current Opinion in Neurobiology. 65: 146–151. doi:10.1016/j.conb.2020.11.003. PMC 7822595. PMID 33254073.
• Pinto, Lucas; Rajan, Kanaka; DePasquale, Brian; Thiberge, Stephan Y.; Tank, David W.; Brody, Carlos D. (November 2019). "Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions". Neuron. 104 (4): 810–824.e9. doi:10.1016/j.neuron.2019.08.025. PMC 7036751. PMID 31564591.
• Yang, Guangyu Robert; Cole, Michael W; Rajan, Kanaka (October 2019). "How to study the neural mechanisms of multiple tasks". Current Opinion in Behavioral Sciences. 29: 134–143. doi:10.1016/j.cobeha.2019.07.001. PMC 7266112. PMID 32490053.
• Andalman, Aaron S.; Burns, Vanessa M.; Lovett-Barron, Matthew; Broxton, Michael; Poole, Ben; Yang, Samuel J.; Grosenick, Logan; Lerner, Talia N.; Chen, Ritchie; Benster, Tyler; Mourrain, Philippe; Levoy, Marc; Rajan, Kanaka; Deisseroth, Karl (May 2019). "Neuronal Dynamics Regulating Brain and Behavioral State Transitions". Cell. 177 (4): 970–985.e20. doi:10.1016/j.cell.2019.02.037. PMC 6726130. PMID 31031000.
• Rajan, Kanaka; Harvey, Christopher; Tank, David (April 2016). "Recurrent Network Models of Sequence Generation and Memory". Neuron. 90 (1): 128–142. arXiv:1603.04687. doi:10.1016/j.neuron.2016.02.009. PMC 4824643. PMID 26971945.
• Rajan, Kanaka; Bialek, William; Samuel, Aravinthan (8 November 2013). "Maximally Informative "Stimulus Energies" in the Analysis of Neural Responses to Natural Signals". PLOS ONE. 8 (11): e71959. Bibcode:2013PLoSO...871959R. doi:10.1371/journal.pone.0071959. PMC 3826732. PMID 24250780.
• Rajan, Kanaka; Marre, Olivier; Tkačik, Gašper (July 2013). "Learning Quadratic Receptive Fields from Neural Responses to Natural Stimuli". Neural Computation. 25 (7): 1661–1692. arXiv:1209.0121. doi:10.1162/NECO_a_00463. PMID 23607557. S2CID 13893466.
• Rajan, Kanaka; Abbott, L. F.; Sompolinsky, Haim (7 July 2010). "Stimulus-dependent suppression of chaos in recurrent neural networks". Physical Review E. 82 (1): 011903. arXiv:0912.3513. Bibcode:2010PhRvE..82a1903R. doi:10.1103/PhysRevE.82.011903. PMC 10683875. PMID 20866644. S2CID 946870.
• Rajan, Kanaka; Abbott, L. F. (2 November 2006). "Eigenvalue Spectra of Random Matrices for Neural Networks". Physical Review Letters. 97 (18): 188104. Bibcode:2006PhRvL..97r8104R. doi:10.1103/PhysRevLett.97.188104. PMID 17155583.