GRB14

GRB14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AUG, 2AUH, 4K81
Identifiers
Aliases	GRB14, growth factor receptor bound protein 14
External IDs	OMIM: 601524; MGI: 1355324; HomoloGene: 3303; GeneCards: GRB14; OMA:GRB14 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.3 Start 164,492,417 bp End 164,621,482 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.3 Start 64,742,820 bp End 64,855,331 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver corpus epididymis left adrenal cortex right adrenal gland right adrenal cortex right testis body of tongue renal medulla left testis body of pancreas Top expressed in interventricular septum vestibular membrane of cochlear duct myocardium of ventricle cardiac muscles right ventricle trigeminal ganglion atrium digastric muscle soleus muscle sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding identical protein binding protein homodimerization activity Cellular component cytoplasm cytosol endosome plasma membrane endosome membrane intracellular membrane-bounded organelle membrane Biological process positive regulation of signal transduction leukocyte migration signal transduction negative regulation of insulin receptor signaling pathway insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2888 50915 Ensembl ENSG00000115290 ENSMUSG00000026888 UniProt Q14449 Q9JLM9 RefSeq (mRNA) NM_001303422 NM_004490 NM_016719 RefSeq (protein) NP_001290351 NP_004481 NP_057928 Location (UCSC) Chr 2: 164.49 – 164.62 Mb Chr 2: 64.74 – 64.86 Mb PubMed search
Wikidata
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Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.

Interactions

GRB14 has been shown to interact with Epidermal growth factor receptor, Fibroblast growth factor receptor 1 and TNKS2.

Further reading

• Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene. 20 (44): 6315–6321. doi:10.1038/sj.onc.1204775. PMID 11607834.
• Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. PMID 8647858.
• Kasus-Jacobi A, Perdereau D, Auzan C, et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions". J. Biol. Chem. 273 (40): 26026–26035. doi:10.1074/jbc.273.40.26026. PMID 9748281.
• Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". J. Biol. Chem. 274 (43): 30896–30905. doi:10.1074/jbc.274.43.30896. PMID 10521483.
• Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. PMID 10713090.
• Hemming R, Agatep R, Badiani K, et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol. 79 (1): 21–32. doi:10.1139/bcb-79-1-21. PMID 11235915.
• Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. PMID 11278563.
• Béréziat V, Kasus-Jacobi A, Perdereau D, et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14". J. Biol. Chem. 277 (7): 4845–4852. doi:10.1074/jbc.M106574200. PMID 11726652.
• Cariou B, Perdereau D, Cailliau K, et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Mol. Cell. Biol. 22 (20): 6959–6970. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1". J. Biol. Chem. 279 (36): 37518–37527. doi:10.1074/jbc.M405340200. PMID 15210700.
• Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain". Protein Sci. 13 (9): 2541–2546. doi:10.1110/ps.04884704. PMC 2280013. PMID 15322292.
• Kairouz R, Parmar J, Lyons RJ, et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466. S2CID 24949216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Depetris RS, Hu J, Gimpelevich I, et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325–333. doi:10.1016/j.molcel.2005.09.001. PMC 4526137. PMID 16246733.
• Park JJ, Berggren JR, Hulver MW, et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics. 27 (2): 114–121. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634.