IKBKB

IKBKB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4KIK, 3BRT, 3BRV, 4E3C
Dynodwyr
Cyfenwau	IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A, IMD15B
Dynodwyr allanol	OMIM: 603258 HomoloGene: 7782 GeneCards: IKBKB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • IkappaB kinase activity • nucleotide binding • protein homodimerization activity • scaffold protein binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • protein kinase binding • protein heterodimerization activity • protein serine/threonine kinase activity • identical protein binding Cydrannau o'r gell • bilen • membrane raft • CD40 receptor complex • cytoplasmic side of plasma membrane • cnewyllyn cell • IkappaB kinase complex • cytoplasm • cytosol Prosesau biolegol • phosphorylation • regulation of tumor necrosis factor-mediated signaling pathway • cellular response to tumor necrosis factor • response to virus • regulation of phosphorylation • negative regulation of apoptotic process • stimulatory C-type lectin receptor signaling pathway • T cell receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • negative regulation of bicellular tight junction assembly • stress-activated MAPK cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of myosin-light-chain-phosphatase activity • innate immune response • inflammatory response • I-kappaB kinase/NF-kappaB signaling • GO:0033109 cortical actin cytoskeleton organization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of establishment of endothelial barrier • I-kappaB phosphorylation • tumor necrosis factor-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • anatomical structure morphogenesis • protein localization to plasma membrane • MyD88-independent toll-like receptor signaling pathway • GO:0035404 peptidyl-serine phosphorylation • interleukin-1-mediated signaling pathway • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3551	n/a
Ensembl	ENSG00000104365	n/a
UniProt	O14920	n/a
RefSeq (mRNA)	NM_001190720 NM_001190721 NM_001190722 NM_001242778 NM_001556	n/a
RefSeq (protein)	NP_001177649 NP_001229707 NP_001547	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IKBKB yw IKBKB a elwir hefyd yn Inhibitor of nuclear factor kappa B kinase subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IKBKB.

• IKK2
• IKKB
• IMD15
• NFKBIKB
• IKK-beta

Llyfryddiaeth

• "Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. ". Redox Biol. 2017. PMID 28107677.
• "Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach. ". Pharm Biol. 2017. PMID 27931154.
• "IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. ". Genes Dev. 2016. PMID 27585591.
• "IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression. ". Oncotarget. 2017. PMID 27577074.
• "Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells.". J Ethnopharmacol. 2016. PMID 27196294.